1-[5-Ethyl-2-hydroxy-4-[[6-methyl-6-(1H-tetrazol-5-YL)heptyl]oxy]phenyl]ethanone

Base Information

Chemical Name:1-[5-Ethyl-2-hydroxy-4-[[6-methyl-6-(1H-tetrazol-5-YL)heptyl]oxy]phenyl]ethanone
CAS No.:117690-79-6
Molecular Formula:C19H28 N4 O3
Molecular Weight:360.456
Hs Code.:2933990090
UNII:H037W1I5AL
DSSTox Substance ID:DTXSID30151872
Nikkaji Number:J302.384B
Wikidata:Q27165308
Pharos Ligand ID:Y6GADLJZCXRQ
ChEMBL ID:CHEMBL15766
Mol file:117690-79-6.mol

Synonyms:(1-(5-ethyl-2-hydroxy-4-(6-methyl-6-(1H-tetrazol-5-yl)heptyloxy)phenyl)ethanone);LY 255283;LY-255283;LY255283

Suppliers and Price of 1-[5-Ethyl-2-hydroxy-4-[[6-methyl-6-(1H-tetrazol-5-YL)heptyl]oxy]phenyl]ethanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
LY 255283
10mg
$ 446.00

TRC
LY-255283
1mg
$ 65.00

Tocris
LY255283 ≥98%(HPLC)
10
$ 185.00

Sigma-Aldrich
LY255283 ≥98% (HPLC), powder
25mg
$ 598.00

Sigma-Aldrich
LY255283 ≥98% (HPLC), powder
5mg
$ 149.00

CSNpharm
LY255283
5mg
$ 95.00

ChemScene
LY255283 ≥98.0%
5mg
$ 375.00

Cayman Chemical
LY255283 ≥98%
1mg
$ 19.00

Cayman Chemical
LY255283 ≥98%
10mg
$ 114.00

Cayman Chemical
LY255283 ≥98%
5mg
$ 76.00

Total 10 raw suppliers

Chemical Property of 1-[5-Ethyl-2-hydroxy-4-[[6-methyl-6-(1H-tetrazol-5-YL)heptyl]oxy]phenyl]ethanone

Chemical Property:

Vapor Pressure:9.45E-14mmHg at 25°C
Melting Point:160-162 °C
Boiling Point:573.4°Cat760mmHg
PKA:5.11±0.10(Predicted)
Flash Point:300.6°C
PSA：100.99000
Density:1.157g/cm³
LogP:3.58730
Storage Temp.:Store at +4°C
Solubility.:DMSO: >20mg/mL
XLogP3:4.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:10
Exact Mass:360.21614077
Heavy Atom Count:26
Complexity:447

Purity/Quality:

98%min ^*data from raw suppliers

LY 255283 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCC1=CC(=C(C=C1OCCCCCC(C)(C)C2=NNN=N2)O)C(=O)C
Description Antagonists of the chemotactic and inflammatory lipoxygenase product leukotriene B4 (LTB4) have been potential drug development targets for several years. The tetrazole LY255283 is a competitive antagonist of the BLT2 receptor. It displaces radiolabeled LTB4 from guinea pig lung membrane, with an IC50 of about 100 nM. LY255283 exhibits IC50 values of ~950 nM and >10 μM at human recombinant BLT2 and BLT1 receptors, respectively. LY255283 inhibits eosinophil chemotaxis by 80% at a concentration of 10 μM, and inhibits the binding of radiolabeled LTB4 to eosinophil membranes with an IC50 of 260 nM.
Uses LY-255283 is a selective, competitive BLT2 receptor antagonist used in the treatment of chronic myeloid leukemia.

Technology Process of 1-[5-Ethyl-2-hydroxy-4-[[6-methyl-6-(1H-tetrazol-5-YL)heptyl]oxy]phenyl]ethanone

There total 8 articles about 1-[5-Ethyl-2-hydroxy-4-[[6-methyl-6-(1H-tetrazol-5-YL)heptyl]oxy]phenyl]ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 117690-81-0
7-(4-acetyl-2-ethyl-5-hydroxyphenoxy)-2,2-dimethylheptanenitrile

: 117690-79-6
1-[5-ethyl-2-hydroxy-4-[[6-methyl-6-(1H-tetrazol-5-yl)heptyl]oxy]phenyl]ethanone

Guidance literature:: With trimethylsilylazide; tetra-n-butylammoniumfluoride trihydrate; In N,N-dimethyl-formamide; at 100 ℃; for 20h; Inert atmosphere; Sealed tube;
DOI:10.1016/j.bmc.2014.01.032