Glycine, N-[[1,6-dihydro-6-oxo-2-[[(phenylmethoxy)carbonyl]amino]-9H-purin-9-yl ]acetyl]-N-[(1S,2S)-2-[[(1,1-dimethylethoxy)carbonyl]amino]cyclohexyl]-, ethyl ester

Base Information

• Chemical Name: Glycine, N-[[1,6-dihydro-6-oxo-2-[[(phenylmethoxy)carbonyl]amino]-9H-purin-9-yl ]acetyl]-N-[(1S,2S)-2-[[(1,1-dimethylethoxy)carbonyl]amino]cyclohexyl]-, ethyl ester
• CAS No.: 193621-94-2
• Molecular Formula: C30H39N7O8
• Molecular Weight: 625.682
• Mol file: 193621-94-2.mol

Synonyms:

Chemical Property of Glycine, N-[[1,6-dihydro-6-oxo-2-[[(phenylmethoxy)carbonyl]amino]-9H-purin-9-yl ]acetyl]-N-[(1S,2S)-2-[[(1,1-dimethylethoxy)carbonyl]amino]cyclohexyl]-, ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Glycine, N-[[1,6-dihydro-6-oxo-2-[[(phenylmethoxy)carbonyl]amino]-9H-purin-9-yl ]acetyl]-N-[(1S,2S)-2-[[(1,1-dimethylethoxy)carbonyl]amino]cyclohexyl]-, ethyl ester

There total 4 articles about Glycine, N-[[1,6-dihydro-6-oxo-2-[[(phenylmethoxy)carbonyl]amino]-9H-purin-9-yl ]acetyl]-N-[(1S,2S)-2-[[(1,1-dimethylethoxy)carbonyl]amino]cyclohexyl]-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-[2-(benzyloxycarbonyl)amino-6-oxo-1,6-dihydro-9H-purin-9-yl]acetic acid (169287-69-8) + ((1S,2S)-2-tert-Butoxycarbonylamino-cyclohexylamino)-acetic acid ethyl ester (193621-90-8) → [[2-(2-Benzyloxycarbonylamino-6-oxo-1,6-dihydro-purin-9-yl)-acetyl]-((1S,2S)-2-tert-butoxycarbonylamino-cyclohexyl)-amino]-acetic acid ethyl ester (193621-94-2)

Guidance literature:

With 3-hydroxy-3,4-dihydrobenzotriazine-4-one; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide; for 4h; Ambient temperature;

DOI:10.1002/chem.19970030613

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → [[2-(2-Benzyloxycarbonylamino-6-oxo-1,6-dihydro-purin-9-yl)-acetyl]-((1S,2S)-2-tert-butoxycarbonylamino-cyclohexyl)-amino]-acetic acid ethyl ester (193621-94-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 73 percent / CH₂Cl₂ / Ambient temperature

2: 65 percent / K₂CO₃ / dimethylformamide / 1.) 0 deg C, 1 h, 2.) r.t., 1 h

3: 80 percent / 3,4-dihydro-3-hydroxy-4-oxo-1,2,3-benzotriazine, DCC / dimethylformamide; CH₂Cl₂ / 4 h / Ambient temperature

With potassium carbonate; 3-hydroxy-3,4-dihydrobenzotriazine-4-one; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/chem.19970030613

Reference yield:

(S,S)-1,2-diaminocyclohexane (21436-03-3) → [[2-(2-Benzyloxycarbonylamino-6-oxo-1,6-dihydro-purin-9-yl)-acetyl]-((1S,2S)-2-tert-butoxycarbonylamino-cyclohexyl)-amino]-acetic acid ethyl ester (193621-94-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 73 percent / CH₂Cl₂ / Ambient temperature

2: 65 percent / K₂CO₃ / dimethylformamide / 1.) 0 deg C, 1 h, 2.) r.t., 1 h

3: 80 percent / 3,4-dihydro-3-hydroxy-4-oxo-1,2,3-benzotriazine, DCC / dimethylformamide; CH₂Cl₂ / 4 h / Ambient temperature

With potassium carbonate; 3-hydroxy-3,4-dihydrobenzotriazine-4-one; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/chem.19970030613

upstream raw materials:

2-[2-(benzyloxycarbonyl)amino-6-oxo-1,6-dihydro-9H-purin-9-yl]acetic acid

((1S,2S)-2-tert-Butoxycarbonylamino-cyclohexylamino)-acetic acid ethyl ester

di-tert-butyl dicarbonate

(S,S)-1,2-diaminocyclohexane