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Technology Process of N-(3-methoxy-2-methyl-16-oxo-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-4-yl)-N-methylbenzamide

N-(3-methoxy-2-methyl-16-oxo-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-4-yl)-N-methylbenzamide

Base Information
  • Chemical Name:N-(3-methoxy-2-methyl-16-oxo-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-4-yl)-N-methylbenzamide
  • CAS No.:120685-11-2
  • Molecular Formula:C35H30 N4 O4
  • Molecular Weight:570.648
  • Hs Code.:29329990
  • European Community (EC) Number:848-383-0
  • ChEMBL ID:CHEMBL5184068
  • Wikidata:Q27163304
  • Wikipedia:Midostaurin
  • Mol file:120685-11-2.mol
N-(3-methoxy-2-methyl-16-oxo-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-4-yl)-N-methylbenzamide

Synonyms:4'-N-benzoyl staurosporine;4'-N-benzoylstaurosporine;benzamide, N-(2,3,9,10,11,12-hexahydro-9-methoxy-8-methyl-1-oxo-8,12-epoxy-1H,8H-2,7b,12a-triazadibenzo(a,g)cyclonona(cde)trinden-10-yl)-N-methyl-, (8alpha,9beta,10beta,12alpha)-;benzoylstaurosporine;CGP 41 251;CGP 41251;CGP-41251;midostaurin;N-((9S,10R,11R,13R)-10-methoxy-9-methyl-1-oxo-2,3,10,11,12,13-hexahydro-9,13-epoxy-1H,9H-diindolo(1,2,3-GH:3',2',1'-lm)pyrrolo(3,4-j)(1,7)benzodiazonin-11-yl)-n-methylbenzamide;PKC 412;PKC-412;PKC412;Rydapt

Suppliers and Price of N-(3-methoxy-2-methyl-16-oxo-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-4-yl)-N-methylbenzamide
Supply Marketing:
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • TRC
  • Midostaurin
  • 1mg
  • $ 50.00
  • Sigma-Aldrich
  • Staurosporine, N-Benzoyl A cell-permeable Staurosporine derivative that displays antitumor properties.
  • 1mg
  • $ 217.37
  • Medical Isotopes, Inc.
  • Midostaurin
  • 1 mg
  • $ 590.00
  • DC Chemicals
  • PKC-412(Midostaurin) >98%
  • 250 mg
  • $ 1300.00
  • DC Chemicals
  • PKC-412(Midostaurin) >98%
  • 100 mg
  • $ 650.00
  • DC Chemicals
  • PKC-412(Midostaurin) >98%
  • 1 g
  • $ 2700.00
  • CSNpharm
  • PKC412
  • 1mg
  • $ 51.00
  • Crysdot
  • PKC412(Midostaurin,CGP41231,CGP41251) 98+%
  • 100mg
  • $ 1896.00
  • Crysdot
  • PKC412(Midostaurin,CGP41231,CGP41251) 98+%
  • 50mg
  • $ 1128.00
  • Crysdot
  • PKC412(Midostaurin,CGP41231,CGP41251) 98+%
  • 10mg
  • $ 447.00
Total 88 raw suppliers
Chemical Property of N-(3-methoxy-2-methyl-16-oxo-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-4-yl)-N-methylbenzamide
Chemical Property:
  • Melting Point:235-260℃ 
  • Boiling Point:°Cat760mmHg 
  • PKA:14.19±0.70(Predicted) 
  • Flash Point:°C 
  • PSA：77.73000 
  • Density:1.46g/cm3 
  • LogP:6.23560 
  • Storage Temp.:Store at 2-8 
  • Solubility.:Soluble in DMSO (15 mg/ml), MDC (10 mg/ml), methanol (5 mg/ml),  
  • XLogP3:4.8
  • Hydrogen Bond Donor Count:1
  • Hydrogen Bond Acceptor Count:4
  • Rotatable Bond Count:3
  • Exact Mass:570.22670545
  • Heavy Atom Count:43
  • Complexity:1140
Purity/Quality:

98%, *data from raw suppliers

Midostaurin *data from reagent suppliers

Safty Information:
  • Pictogram(s):  
  • Hazard Codes:T 
  • Statements: 36/37/38 
MSDS Files:

SDS file from LookChem

Useful:
  • Canonical SMILES:CC12C(C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)N(C)C(=O)C9=CC=CC=C9)OC
  • Recent EU Clinical Trials:Midostaurin + Gemtuzumab Ozogamicin combination in first-line standard therapy for acute myeloid leukemia
  • Description PKC-412 (120685-11-2) is a broad spectrum kinase inhibitor. Inhibited kinases include, but are not limited to; PKA, PKC, S6 Kinase, KDR, PKC, Akt, EGFR, VEGFR, PDGFR, c-kit, and FLT-3. Acute myeloid leukemia related mutant forms of FLT-3 are also inhibited both in vitro and in vivo. PKC-412 has been demonstrated to induce apoptosis and shows broad antiproliferative activity in various tumor cell lines. Cell Permeable
  • Uses Midostaurin was shown to possess antiproliferative characteristics via inhibition of protein kinase C, kinase insert domain receptor, and c-kit. Midostaurin is used as a broad spectrum protein kinase inhibitor. Inhibits conventional PKC isoforms (α, β, γ), PDFRβ, VEGFR2, Syk, PKCη, Flk-1, Flt3, Cdk1/B, PKA, c-Kit, c-Fgr, c-Src, VEGFR1 and EGFR. Displays potent antitumor activity. Due to this act which may result in disruption of the cell cycle, inhibition of proliferation, apoptosis, and inhibition of angiogenesis in susceptible tumors. Midostaurin was shown to possess antiproliferative characteristics via inhibition of protein kinase C, kinase insert domain receptor, and c-kit.
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