ISATIN-3-OXIME

Base Information

• Chemical Name: ISATIN-3-OXIME
• CAS No.: 607-28-3
• Molecular Formula: C₈H₆N₂O₂
• Molecular Weight: 162.148
• Hs Code.: 2933790090
• Mol file: 607-28-3.mol

Synonyms:Indole-2,3-dione,3-oxime (7CI,8CI);Isatin, 3-oxime (6CI);Isatin b-oxime;NSC 9355;

Chemical Property of ISATIN-3-OXIME

Chemical Property:

• Vapor Pressure: 4.43E-08mmHg at 25°C
• Melting Point: 228°C (dec.)
• Refractive Index: 1.706
• Boiling Point: 400.5 °C at 760 mmHg
• PKA: 9.19±0.20(Predicted)
• Flash Point: 196 °C
• PSA: 61.69000
• Density: 1.49 g/cm³
• LogP: 0.95500

Purity/Quality:

98%,99%, ^*data from raw suppliers

β-Isatoxime [for Metal Analysis] >98.0%(HPLC)(T) ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ISATIN-3-OXIME

There total 29 articles about ISATIN-3-OXIME which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

indole-2,3-dione (91-56-5,1186480-61-4,84788-92-1) → (E)-1H-indole-2,3-dione 3-oxime (607-28-3,73859-64-0,73859-66-2)

Guidance literature:

With hydroxylamine; In methanol; Reflux;

DOI:10.2174/1570180812666150514234029

Reference yield: 89.0%

2-nitroacetanilide (10151-95-8) → (E)-1H-indole-2,3-dione 3-oxime (607-28-3,73859-64-0,73859-66-2)

Guidance literature:

With trifluorormethanesulfonic acid; Ambient temperature;

DOI:10.1055/s-1992-26223

Reference yield: 68.0%

aniline (62-53-3) + 2,3-indoledione-3-oxime O-acetate (762241-88-3) → Isatin-3-oxime (607-28-3,73859-64-0,73859-66-2) + Acetanilid (103-84-4)

Guidance literature:

In acetonitrile; for 0.333333h; Heating;

DOI:10.1007/s10593-005-0114-7

upstream raw materials:

2-oxoindole

hydroxyimino-N-phenylacetamide

nitromethane

indole-2,3-dione

Downstream raw materials:

indole-2,3-dione

(3-hydroxy-2-oxo-2,3-dihydro-indol-3-yl)-phosphonic acid diisopropyl ester

dimethyl (3-hydroxy-2-oxo-1H-indol-3-yl) phosphonate

diethyl 3-hydroxy-2-oxo-2,3-dihydro-1H-indol-3-yl phosphonate

Refernces

• 1、 Pinto, Angelo C.,Lapis, Alexandre A. Moreira,da Silva, Barbara Vasconcellos,Bastos, Renato S.,Dupont, Ja?rton,Neto, Brenno A.D.. "Pronounced ionic liquid effect in the synthesis of biologically active isatin-3-oxime derivatives under acid catalysis". . p. 5639 - 5641. Retrieved 2008.
• 2、 Dawar, Monika,Kaur, Komalpreet,Rani, Ritu,Utreja, Divya. "Synthesis and evaluation of isatin derivatives as antifungal agents". . p. 199 - 205. Retrieved 2020/02/29.
• 3、 Cavalcante, Samir F. de A.,Kitagawa, Daniel A.S.,Rodrigues, Rafael B.,Bernardo, Leandro B.,da Silva, Thiago N.,dos Santos, Wellington V.,Correa, Ana Beatriz de A.,de Almeida, Joyce S.F.D.,Fran?a, Tanos C.C.,Ku?a, Kamil,Simas, Alessandro B.C.. "Synthesis and in vitro evaluation of neutral aryloximes as reactivators of Electrophorus eel acetylcholinesterase inhibited by NEMP, a VX surrogate". . . Retrieved 2019/06/24.