6-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-ylamine hydrochloride

Base Information

• Chemical Name: 6-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-ylamine hydrochloride
• CAS No.: 4003-88-7
• Molecular Formula: C11H16ClNO
• Molecular Weight: 213.7038
• European Community (EC) Number: 831-309-6
• ChEMBL ID: CHEMBL535852
• DSSTox Substance ID: DTXSID60960494
• Mol file: 4003-88-7.mol

Synonyms:4003-88-7;6-METHOXY-1,2,3,4-TETRAHYDRO-NAPHTHALEN-2-YLAMINE HYDROCHLORIDE;6-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine hydrochloride;86554-90-7;(6-methoxytetralin-2-yl)ammonium chloride;(R)-6-Methoxy-2-aminotetralin hydrochloride;(S)-6-methoxy-2-aminotetralin hydrochloride;CHEMBL535852;SCHEMBL2991649;DTXSID60960494;VANKCRQVOCWUPP-UHFFFAOYSA-N;6-methoxy-1,2,3,4-tetrahydronaphthalen-2-ylamine hydrochloride;MFCD01712014;6-METHOXY-1,2,3,4-TETRAHYDRO-NAPHTHALEN-2-YLAMINEHYDROCHLORIDE;AKOS024262152;AB09822;SB37038;AS-82808;CS-0172612;FT-0727200;C91698;EN300-132825;6-methoxy-1,2,3,4-tetrahydronaphthalen-2-ylamine HCl;6-METHOXY-1,2,3,4-TETRAHYDRONAPHTHALEN-2-AMINE HCL;6-Methoxy-1,2,3,4-tetrahydronaphthalen-2-aminehydrochloride;2-amino-6-methoxy-1,2,3,4-tetrahydro-naphthalene hydrochloride;6-Methoxy-1,2,3,4-tetrahydronaphthalen-2-amine--hydrogen chloride (1/1)

Chemical Property of 6-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-ylamine hydrochloride

Chemical Property:

• Vapor Pressure: 0.00118mmHg at 25°C
• Melting Point: 234-236 °C
• Boiling Point: 299.6°Cat760mmHg
• Flash Point: 139.7°C
• PSA: 0.00000
• Density: g/cm³
• LogP: 0.00000
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 213.0920418
• Heavy Atom Count: 14
• Complexity: 172

Purity/Quality:

97% ^*data from raw suppliers

6-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-ylamineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC2=C(CC(CC2)N)C=C1.Cl
• Uses: 6-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-ylamine Hydrochloride is a 2-aminotetralin derivative used for as antifungal agents.

Technology Process of 6-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-ylamine hydrochloride

There total 5 articles about 6-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-ylamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

2-benzylamino-6-methoxy-1,2,3,4-tetrahydro-naphthalene hydrochloride → 2-amino-6-methoxy-1,2,3,4-tetrahydronaphthalene hydrochloride (4003-88-7,86554-88-3,86554-90-7,1229244-88-5,1229244-90-9)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; at 20 ℃; for 24h; under 3102.97 Torr;

Reference yield: 50.0%

6-methoxy-2-tetralone (2472-22-2) → 2-amino-6-methoxy-1,2,3,4-tetrahydronaphthalene hydrochloride (4003-88-7,86554-88-3,86554-90-7,1229244-88-5,1229244-90-9)

Guidance literature:

6-methoxy-2-tetralone; With ammonium acetate; In methanol; at 20 ℃; for 0.5h;

With sodium cyanoborohydride; for 1 - 2h; Heating / reflux;

Reference yield: 42.0%

→ 2-amino-6-methoxy-1,2,3,4-tetrahydronaphthalene hydrochloride (4003-88-7,86554-88-3,86554-90-7,1229244-88-5,1229244-90-9)

Guidance literature:

upstream raw materials:

2-amino-6-methoxy-1,2,3,4-tetrahydronaphthalene

6-methoxy-2-tetralone

toluene-4-sulfonic acid

benzylamine