L-Valinamide, N-[[[(1S)-2-(1,1-dimethylethoxy)-2-oxo-1-(phenylmethyl)ethyl]amino]carb onyl]-L-alanyl-N-[(1S)-2,2-dimethoxy-1-(phenylmethyl)ethyl]-

Base Information

Chemical Name:L-Valinamide, N-[[[(1S)-2-(1,1-dimethylethoxy)-2-oxo-1-(phenylmethyl)ethyl]amino]carb onyl]-L-alanyl-N-[(1S)-2,2-dimethoxy-1-(phenylmethyl)ethyl]-
CAS No.:194020-73-0
Molecular Formula:C33H48N4O7
Molecular Weight:612.767
Hs Code.:

L-Valinamide,
N-[[[(1S)-2-(1,1-dimethylethoxy)-2-oxo-1-(phenylmethyl)ethyl]amino]carb
onyl]-L-alanyl-N-[(1S)-2,2-dimethoxy-1-(phenylmethyl)ethyl]-

Synonyms:

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Chemical Property of L-Valinamide, N-[[[(1S)-2-(1,1-dimethylethoxy)-2-oxo-1-(phenylmethyl)ethyl]amino]carb onyl]-L-alanyl-N-[(1S)-2,2-dimethoxy-1-(phenylmethyl)ethyl]-

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Technology Process of L-Valinamide, N-[[[(1S)-2-(1,1-dimethylethoxy)-2-oxo-1-(phenylmethyl)ethyl]amino]carb onyl]-L-alanyl-N-[(1S)-2,2-dimethoxy-1-(phenylmethyl)ethyl]-

There total 7 articles about L-Valinamide, N-[[[(1S)-2-(1,1-dimethylethoxy)-2-oxo-1-(phenylmethyl)ethyl]amino]carb onyl]-L-alanyl-N-[(1S)-2,2-dimethoxy-1-(phenylmethyl)ethyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 194020-71-8
(S)-2-Amino-N-((S)-1-benzyl-2,2-dimethoxy-ethyl)-3-methyl-butyramide

: 194020-65-0
(S)-2-[3-((S)-1-Carboxy-ethyl)-ureido]-3-phenyl-propionic acid tert-butyl ester

: 194020-73-0
(S)-2-(3-{(S)-1-[(S)-1-((S)-1-Benzyl-2,2-dimethoxy-ethylcarbamoyl)-2-methyl-propylcarbamoyl]-ethyl}-ureido)-3-phenyl-propionic acid tert-butyl ester

Guidance literature:: With diphenyl phosphoryl azide; triethylamine; In N,N-dimethyl-formamide; 1) 0 deg C, 4 h; 2) rt, overnight;
DOI:10.1021/jo970514p

Reference yield:

: 1149-26-4
(S)-N-(benzyloxycarbonyl)valine

: 194020-73-0
(S)-2-(3-{(S)-1-[(S)-1-((S)-1-Benzyl-2,2-dimethoxy-ethylcarbamoyl)-2-methyl-propylcarbamoyl]-ethyl}-ureido)-3-phenyl-propionic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 85 percent / DCC, N-hydroxybenzotriazole / tetrahydrofuran / Ambient temperature

2: 88 percent / Dess-Martin reagent / CH₂Cl₂ / 1 h

3: 61 percent / p-toluenesulfonic acid / methanol / 4 h / Heating

4: 97 percent / H₂ / Pd-C / methanol / 2 h

5: 60 percent / diphenylphosphorazidate, Et₃N / dimethylformamide / 1) 0 deg C, 4 h; 2) rt, overnight

With diphenyl phosphoryl azide; hydrogen; benzotriazol-1-ol; Dess-Martin periodane; toluene-4-sulfonic acid; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo970514p

Reference yield:

: 3182-95-4
L-Phenylalaninol

: 194020-73-0
(S)-2-(3-{(S)-1-[(S)-1-((S)-1-Benzyl-2,2-dimethoxy-ethylcarbamoyl)-2-methyl-propylcarbamoyl]-ethyl}-ureido)-3-phenyl-propionic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 85 percent / DCC, N-hydroxybenzotriazole / tetrahydrofuran / Ambient temperature

2: 88 percent / Dess-Martin reagent / CH₂Cl₂ / 1 h

3: 61 percent / p-toluenesulfonic acid / methanol / 4 h / Heating

4: 97 percent / H₂ / Pd-C / methanol / 2 h

5: 60 percent / diphenylphosphorazidate, Et₃N / dimethylformamide / 1) 0 deg C, 4 h; 2) rt, overnight

With diphenyl phosphoryl azide; hydrogen; benzotriazol-1-ol; Dess-Martin periodane; toluene-4-sulfonic acid; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo970514p