N-acetylseryl-leucyl-asparaginyl(phenylalanyl-hydroxyethylamino-prolyl)isoleucyl-valyl methyl ester

Base Information

Chemical Name:N-acetylseryl-leucyl-asparaginyl(phenylalanyl-hydroxyethylamino-prolyl)isoleucyl-valyl methyl ester
CAS No.:127231-42-9
Molecular Formula:C42H68 N8 O11
Molecular Weight:861.03632
Hs Code.:
Mol file:127231-42-9.mol

Synonyms:L-Valine,N-[N-[1-[3-[[N2-[N-(N-acetyl-L-seryl)-L-leucyl]-L-asparaginyl]amino]-2-hydroxy-4-phenylbutyl]-L-prolyl]-L-isoleucyl]-,methyl ester, [S-(R*,R*)]-; (S)-JG 365

Suppliers and Price of N-acetylseryl-leucyl-asparaginyl(phenylalanyl-hydroxyethylamino-prolyl)isoleucyl-valyl methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of N-acetylseryl-leucyl-asparaginyl(phenylalanyl-hydroxyethylamino-prolyl)isoleucyl-valyl methyl ester

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Boiling Point:1216.5°Cat760mmHg
Flash Point:689.5°C
PSA：309.62000
Density:1.207g/cm³
LogP:4.90140

Purity/Quality:: 98%min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of N-acetylseryl-leucyl-asparaginyl(phenylalanyl-hydroxyethylamino-prolyl)isoleucyl-valyl methyl ester

There total 23 articles about N-acetylseryl-leucyl-asparaginyl(phenylalanyl-hydroxyethylamino-prolyl)isoleucyl-valyl methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 127231-61-2,127306-23-4,137328-45-1
(2RS,3S)-3-<(N-acetyl-O-benzylserinylleucinylasparaginyl)amino>-2-hydroxy-4-phenyl-1-(N-prolylisoleucylvaline methyl ester)butane

: 127231-42-9,127306-15-4,132748-20-0
Ac-Ser-Leu-Asn--Ile-Val-OMe

Guidance literature:: With hydrogen; palladium dihydroxide; In acetic acid; for 4h;
DOI:10.1021/jm00099a008

Reference yield:

: 127231-43-0
(3S)-<(N-acetyl-O-benzylserinylleucinylasparaginyl)amino>-1-chloro-4-phenyl-2-butanone

: 127231-42-9,127306-15-4,132748-20-0
Ac-Ser-Leu-Asn--Ile-Val-OMe

Guidance literature:: Multi-step reaction with 3 steps

1: NaI, NaHCO₃ / dimethylformamide / 18 h / Ambient temperature

2: NaBH₄ / methanol

3: 99 percent / H₂ / 10percent Pd(OH)2/C / aq. acetic acid / 4 h

With sodium tetrahydroborate; hydrogen; sodium hydrogencarbonate; sodium iodide; palladium dihydroxide; In methanol; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm00099a008

Reference yield:

: (S)-2-Amino-N¹-((S)-1-benzyl-3-chloro-2-oxo-propyl)-succinamide

: 127231-42-9,127306-15-4,132748-20-0
Ac-Ser-Leu-Asn--Ile-Val-OMe

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) hydroxybenzotriazole (HOBt), EDCI, 2.) N-methylmorpholine (NMM) / 1.) DMF, 40 min, 2.) DMF, a) 0 deg C, 2 h, b) RT, overnight

2: 4 N HCl / dioxane / 1 h / Ambient temperature

3: 1.) hydroxybenzotriazole (HOBt), EDCI, 2.) N-methylmorpholine (NMM) / 1.) DMF, 40 min, 2.) DMF, a) 0 deg C, 2 h, b) RT, overnight

4: 4 N HCl / dioxane / 1 h / Ambient temperature

5: triethylamine, DCM / dimethylformamide / 2 h / 0 - 20 °C

6: NaI, NaHCO₃ / dimethylformamide / 18 h / Ambient temperature

7: NaBH₄ / methanol

8: 99 percent / H₂ / 10percent Pd(OH)2/C / aq. acetic acid / 4 h

With 4-methyl-morpholine; hydrogenchloride; sodium tetrahydroborate; hydrogen; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; sodium hydrogencarbonate; benzotriazol-1-ol; triethylamine; sodium iodide; palladium dihydroxide; In 1,4-dioxane; methanol; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm00099a008