1-((2-Hydroxyethoxy)methyl)-(E)-5-(2-bromovinyl)uracil

Base Information

Chemical Name:1-((2-Hydroxyethoxy)methyl)-(E)-5-(2-bromovinyl)uracil
CAS No.:91897-93-7
Molecular Formula:C₉H₁₁BrN₂O₄
Molecular Weight:291.101
Hs Code.:
ChEMBL ID:CHEMBL33917

Synonyms:91897-93-7;1-((2-Hydroxyethoxy)methyl)-(E)-5-(2-bromovinyl)uracil;1-[(2-Hydroxyethoxy)methyl]-(E)-5-(2-bromovinyl)uracil;CHEMBL33917;5-[(E)-2-bromovinyl]-4-hydroxy-1-(2-hydroxyethoxymethyl)pyrimidin-2-one

Suppliers and Price of 1-((2-Hydroxyethoxy)methyl)-(E)-5-(2-bromovinyl)uracil

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 0 raw suppliers

Chemical Property of 1-((2-Hydroxyethoxy)methyl)-(E)-5-(2-bromovinyl)uracil

Chemical Property:

Boiling Point:°Cat760mmHg
Flash Point:°C
Density:1.729g/cm³
XLogP3:-0.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:289.99022
Heavy Atom Count:16
Complexity:340

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=C(C(=O)NC(=O)N1COCCO)C=CBr
Isomeric SMILES:C1=C(C(=O)NC(=O)N1COCCO)/C=C/Br

Technology Process of 1-((2-Hydroxyethoxy)methyl)-(E)-5-(2-bromovinyl)uracil

There total 3 articles about 1-((2-Hydroxyethoxy)methyl)-(E)-5-(2-bromovinyl)uracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 85267-69-2
(E)-2-((5-(2-bromovinyl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methoxy)ethyl acetate

: 91897-93-7
(E)-5-(2-bromovinyl)-1-((2-hydroxyethoxy)methyl)pyrimidine-2,4(1H,3H)-dione

Guidance literature:: With ammonia; In methanol; for 5h; Ambient temperature;
DOI:10.1139/v82-081

Reference yield:

: 73446-72-7
2,4-bis-O-(trimethylsilyl)-(E)-5-(2-bromovinyl)uracil

: 91897-93-7
(E)-5-(2-bromovinyl)-1-((2-hydroxyethoxy)methyl)pyrimidine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) acetonitrile, 0 degC, 2.) 0 degC to R_.T_. 2 h

2: 91 percent / NH₃ / methanol / 5 h / Ambient temperature

With ammonia; In methanol;
DOI:10.1139/v82-081

Reference yield:

: 69304-49-0
(E)-5-(2-bromovinyl)uracil

: 91897-93-7
(E)-5-(2-bromovinyl)-1-((2-hydroxyethoxy)methyl)pyrimidine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 3 steps

1: chlorotrimethylsilane / Heating

2: 1.) acetonitrile, 0 degC, 2.) 0 degC to R_.T_. 2 h

3: 91 percent / NH₃ / methanol / 5 h / Ambient temperature

With chloro-trimethyl-silane; ammonia; In methanol;
DOI:10.1139/v82-081