ANP 1-28, HUMAN

Base Information

• Chemical Name: ANP 1-28, HUMAN
• CAS No.: 89213-87-6
• Molecular Formula: C127H203N45O39S3
• Molecular Weight: 3080.48
• Mol file: 89213-87-6.mol

Synonyms:Atriopeptin-33(rat), 1-de-L-leucine-2-de-L-alanine-3-deglycine-4-de-L-proline-5-de-L-arginine-17-L-methionine-;1,2-Dithia-5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50-hexadecaazacyclotripentacontane,cyclic peptide deriv.;(1-28)-Human atrial natriuretic peptide;13: PN:US20060171920 SEQID: 13 claimed protein;2: PN: US6028055 SEQID: 51 claimedprotein;4: PN: US20090011997 SEQID: 2 claimed protein;56: PN: US20090011997SEQID: 59 claimed protein;82: PN: US20080153747 SEQID: 82 claimed protein;Atriopeptin (human a-component);Carperitide;Horse atrial natriuretic peptide-28;Humanatrial natriuretic factor (99-126);Human atrial natriuretic peptide (1-28);Human atrial natriuretic peptide (99-126);Human atriopeptin(1-28);Humanatriopeptin(99-126);Human atriopeptin-28;Human a-atrial natriuretic factor;Human a-atrial natriuretic factor(1-28);Human a-atrial natriuretic peptide;Human a-atriopeptin;L-Tyrosine,L-seryl-L-leucyl-L-arginyl-L-arginyl-L-seryl-L-seryl-L-cysteinyl-L-phenylalanylglycylglycyl-L-arginyl-L-methionyl-L-a-aspartyl-L-arginyl-L-isoleucylglycyl-L-alanyl-L-glutaminyl-L-serylglycyl-L-leucylglycyl-L-cysteinyl-L-asparaginyl-L-seryl-L-phenylalanyl-L-arginyl-,cyclic (7?;SUN 4936;[99-126]-Human proatriopeptin;a-Atriopeptin (human);a-Human atrial natriuretic hormone;a-Human atrial natriuretic peptide (1-28);a-Human atrial natriureticpolypeptide;a-Humanatriopeptin(1-28);

Chemical Property of ANP 1-28, HUMAN

Chemical Property:

• Refractive Index: 1.688
• PSA: 1479.28000
• Density: 1.55 g/cm³
• LogP: -2.10540

Purity/Quality:

95% ^*data from raw suppliers

AtrialNatriureticFactor(1-28)(human,porcine) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: Carperitide is the α-human atrial natriuretic peptide (α-hANP) produced by recombinant technology. It was introduced in Japan as a treatment for acute congestive heart failure (CHF). In dogs with CHF, carperitide significantly reduced the elevated left ventricular end-diastolic pressure and the index of myocardial oxygen consumption (systolic blood pressure x heart rate). In a clinical trial, carperitide was effective in improving hemodynamics and symptoms in 60% of patients with acute CHF. Carperitide was reported to be well tolerated with no significant adverse effects clinically. A beneficial effect on hemodynamics has been reported in chronic heart failure patients. Carperitide is also in clinical trials for maintenance of blood pressure during surgical operations. Atrial natriuretic peptide (ANP) is an endogenous peptide generated by proteolysis of prepro-ANP that is secreted by cardiomyocytes in the heart. It has effects on the renal and cardiovascular systems that decrease vasoconstriction, inhibit renin secretion, and increase sodium excretion. Human ANP binds to ANP receptors on cultured vascular smooth muscle cells (VSMCs) with a Kd value of approximately 1-2 nM and increases cGMP levels in a dose-dependent manner. It relaxes potassium-induced contraction of isolated canine renal arterial strips when used at concentrations of 10 and 100 ng/ml and dilates renal arteries in anesthetized dogs when used at doses ranging from 10 to 100 ng/kg. In a rat model of heart failure following experimental autoimmune myocarditis, human ANP, via osmotic mini pump for 28 days, decreases cardiomyocyte size as well as the amount of cardiac fibrosis and left ventricular remodeling. ANP (1-28) (human) is a 28 amino acid peptide corresponding to the human protein sequence.
• Uses: Treatment of decompensated congestive heart failure.

Technology Process of ANP 1-28, HUMAN

There total 1 articles about ANP 1-28, HUMAN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

atrial natriuretic peptide (91917-63-4) → human atrial natriuretic peptide (89213-87-6)

Guidance literature:

With methyl 6-(methoxythio)-5-nitronicotinate; In water; acetonitrile; at 20 ℃; for 24h; pH=6;

DOI:10.1002/chem.201700952

upstream raw materials:

atrial natriuretic peptide

Refernces

• 1、 -. "Selective disulfidation reagent using nitrogen-containing compound and method for producing disulfide-containing compound". Page/Page column 28-30. . Retrieved 2020/12/02.