Technology Process of 2-Pentenoic acid, 4-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-,
1,1-dimethylethyl ester, (E)-
There total 2 articles about 2-Pentenoic acid, 4-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-,
1,1-dimethylethyl ester, (E)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: imidazole / CH2Cl2 / Ambient temperature
2: i-Bu2AlH / toluene / 1.58 h / -78 °C
3: 1.) NaH / 1) n-hexane, 0 deg C, 30 min; 2) n-hexane, 0 deg C, 15 min, rt, 1 h
4: 1.) n-BuLi / 1) n-hexane, THF, 0 deg C, 1 h; 2) n-hexane, THF, 0 deg C, overnight, rt, 2 h
With
1H-imidazole; n-butyllithium; sodium hydride; diisobutylaluminium hydride;
In
dichloromethane; toluene;
DOI:10.1021/jo970435d
- Guidance literature:
-
Multi-step reaction with 3 steps
1: i-Bu2AlH / toluene / 1.58 h / -78 °C
2: 1.) NaH / 1) n-hexane, 0 deg C, 30 min; 2) n-hexane, 0 deg C, 15 min, rt, 1 h
3: 1.) n-BuLi / 1) n-hexane, THF, 0 deg C, 1 h; 2) n-hexane, THF, 0 deg C, overnight, rt, 2 h
With
n-butyllithium; sodium hydride; diisobutylaluminium hydride;
In
toluene;
DOI:10.1021/jo970435d
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1.) n-BuLi / 1) THF, n-hexane, -78 deg C, 30 min; 2) THF, n-hexane, 1.5 h, -78 deg C
2: 1.) LDA, 3.) pyridine / 1) THF, -78 deg C, 20 min; 2) THF, -78 deg C, 1.5 h; 3) rt, 1 h
3: 1.) CF3CO2H, 2.) PPh3, 2,2'-dipyridyl disulfide / 1) CH2Cl2, rt, overnight; 2) CH3CN, reflux, 10 h
4: 77 percent / tetrabutylammonium fluoride / tetrahydrofuran / 4 h / Ambient temperature
5: 92 percent / Ph3P, CCl4 / 24 h / Heating
6: K2CO3 / methanol; H2O / 2 h
With
pyridine; tetrachloromethane; n-butyllithium; 2,2'-dipyridyldisulphide; tetrabutyl ammonium fluoride; potassium carbonate; triphenylphosphine; trifluoroacetic acid; lithium diisopropyl amide;
In
tetrahydrofuran; methanol; water;
DOI:10.1021/jo970435d
