4,6-Bis[(4-methylphenyl)sulfanyl]pyrimidin-2-amine

Base Information

• Chemical Name: 4,6-Bis[(4-methylphenyl)sulfanyl]pyrimidin-2-amine
• CAS No.: 7226-50-8
• Molecular Formula: C18H17N3S2
• Molecular Weight: 339.4777
• DSSTox Substance ID: DTXSID40412249
• Nikkaji Number: J1.738.860F
• Mol file: 7226-50-8.mol

Synonyms:7226-50-8;4,6-bis[(4-methylphenyl)sulfanyl]pyrimidin-2-amine;DTXSID40412249

Chemical Property of 4,6-Bis[(4-methylphenyl)sulfanyl]pyrimidin-2-amine

Chemical Property:

• Vapor Pressure: 3.86E-14mmHg at 25°C
• Boiling Point: 595.3°Cat760mmHg
• Flash Point: 313.8°C
• Density: 1.31g/cm³
• XLogP3: 5.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 4
• Exact Mass: 339.08638990
• Heavy Atom Count: 23
• Complexity: 320

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)SC2=CC(=NC(=N2)N)SC3=CC=C(C=C3)C

Technology Process of 4,6-Bis[(4-methylphenyl)sulfanyl]pyrimidin-2-amine

There total 3 articles about 4,6-Bis[(4-methylphenyl)sulfanyl]pyrimidin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C10H22O5S2 + acetic anhydride (108-24-7) → 2,3,4,5,6-penta-O-acetyl-D-mannose diethyl dithioacetal (4984-72-9,5115-87-7,5505-29-3,6935-10-0,7226-25-7,7226-50-8,7226-51-9,7226-53-1,7226-54-2,7260-88-0,72003-68-0)

Guidance literature:

With pyridine; at 0 - 20 ℃; for 19h;

DOI:10.1016/j.tetlet.2012.12.048

Reference yield:

DL-galactose-diethyldithioacetal (1941-52-2,4258-05-3,4258-07-5,4435-00-1,5463-33-2,6748-69-2,15354-64-0,18545-97-6,64813-43-0,76945-90-9,86334-49-8) + acetic anhydride (108-24-7) → penta-O-acetyl-aldehydo-DL-galactose-diethyldithioacetal (4984-72-9,5115-87-7,5505-29-3,6935-10-0,7226-25-7,7226-50-8,7226-51-9,7226-53-1,7226-54-2,7260-88-0,72003-68-0)

Guidance literature:

With pyridine;

DOI:10.1246/bcsj.26.463

Reference yield:

D-galactose diethyl dithioacetal (18545-97-6) + acetic anhydride (108-24-7) → penta-O-acetyl-D-allose diethyl dithioacetal (7226-50-8)

Guidance literature:

With pyridine; at 20 ℃; for 18h;

DOI:10.1016/S0008-6215(00)85192-7

upstream raw materials:

DL-galactose-diethyldithioacetal

acetic anhydride

D-galactose diethyl dithioacetal