DITHIOBIS[2-AMINO-4-METHYLPENTANE] DIHYDROCHLORIDE

Base Information

• Chemical Name: DITHIOBIS[2-AMINO-4-METHYLPENTANE] DIHYDROCHLORIDE
• CAS No.: 88264-65-7
• Molecular Formula: C₆H₁₅NS
• Molecular Weight: 133.258
• Hs Code.: 2930909090
• Mol file: 88264-65-7.mol

Synonyms:1-Pentanethiol,2-amino-4-methyl-, (S)-; (S)-(1-Mercaptomethyl-3-methylbutyl)amine;L-Leucinthiol

Chemical Property of DITHIOBIS[2-AMINO-4-METHYLPENTANE] DIHYDROCHLORIDE

Chemical Property:

• Vapor Pressure: 0.836mmHg at 25°C
• Boiling Point: 181.8°C at 760 mmHg
• Flash Point: 63.8°C
• PSA: 64.82000
• Density: 0.912g/cm³
• LogP: 1.98990
• Storage Temp.: −20°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

L-Leucinethiol, oxidized dihydrochloride leucine aminopeptidase inhibitor ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: Upon reduction in vivo to L-leucinethiol, compound is a potent inhibitor of leucine aminopeptidase.

Technology Process of DITHIOBIS[2-AMINO-4-METHYLPENTANE] DIHYDROCHLORIDE

There total 3 articles about DITHIOBIS[2-AMINO-4-METHYLPENTANE] DIHYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

(S)-2-(2-Methylpropyl)-aziridine (23852-57-5) → (S)-2-amino-4-methyl-1-pentanethiol (88264-65-7)

Guidance literature:

With hydrogen sulfide; In ethanol; at -78 - 25 ℃;

DOI:10.1021/jm00156a012

Reference yield: 38.0%

(S)-1-(bromomethyl)-3-methylbutylammonium bromide (13892-89-2,86447-31-6,86447-32-7) → (S)-2-amino-4-methyl-1-pentanethiol (88264-65-7)

Guidance literature:

(S)-1-(bromomethyl)-3-methylbutylammonium bromide; With thiourea; In ethanol; for 15h; Heating;

With N-(2-aminoethyl)-N'-{2-[(2-aminoethyl)amino]ethyl}ethane-1,2-diamine; In ethanol; for 1h; Heating;

DOI:10.1002/hlca.200490021

Reference yield:

(S)-2-amino-4-methylpentan-1-ol (7533-40-6,14438-11-0) → (S)-2-amino-4-methyl-1-pentanethiol (88264-65-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: HBr / methanol

1.2: 61 percent / PBr₃ / 1.5 h / 70 °C

2.1: NH₂CSNH₂ / ethanol / 15 h / Heating

2.2: 38 percent / tetraethylenepentamine / ethanol / 1 h / Heating

With hydrogen bromide; thiourea; In methanol; ethanol;

DOI:10.1002/hlca.200490021

upstream raw materials:

(S)-2-(2-Methylpropyl)-aziridine

(S)-1-(bromomethyl)-3-methylbutylammonium bromide

(S)-2-amino-4-methylpentan-1-ol

Downstream raw materials:

*,R^*)>-phenylmethyl 2-<<<1-<<(carboxymethyl)thio>methyl>-3-methylbutyl>amino>methyl>-1-pyrrolidinecarboxylate

[S-(R*,R*)]-2-[[[1-[[[2-(1,1-Dimethylethoxy)-2-oxoethyl]thio]methyl]-3-methylbutyl]amino]methyl]-1-pyrrolidinecarboxylic acid, phenylmethyl ester

<2S-(R^*,R^*)>-phenylmethyl 2-<<<1-<<(carboxymethyl)thio>methyl>-3-methylbutyl>amino>carbonyl>-1-pyrrolidinecarboxylate

*,R^*)>-phenylmethyl 2-<<<1-<<(2-amino-2-oxoethyl)thio>methyl>-3-methylbutyl>amino>carbonyl>-1-pyrrolidinecarboxylate