2-(4-Bromophenyl)tetrahydrofuran

Base Information

• Chemical Name: 2-(4-Bromophenyl)tetrahydrofuran
• CAS No.: 194725-15-0
• Molecular Formula: C10H11BrO
• European Community (EC) Number: 874-701-2
• Nikkaji Number: J864.625B
• Mol file: 194725-15-0.mol

Synonyms:2-(4-bromophenyl)tetrahydrofuran;194725-15-0;2-(4-BROMOPHENYL)OXOLANE;MFCD19320036;C10H11BrO;Furan, 2-(4-bromophenyl)tetrahydro-;SCHEMBL9772595;OUJWSBTVHIGHIS-UHFFFAOYSA-N;AKOS022346929;AS-43048;SY235856;EN300-7862074;A1-28850

Chemical Property of 2-(4-Bromophenyl)tetrahydrofuran

Chemical Property:

• XLogP3: 2.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 225.99933
• Heavy Atom Count: 12
• Complexity: 141

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CC(OC1)C2=CC=C(C=C2)Br

Technology Process of 2-(4-Bromophenyl)tetrahydrofuran

There total 12 articles about 2-(4-Bromophenyl)tetrahydrofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.54%

4-chloro-1-(4-bromophenyl)-1-butanol → rac-2-(4-bromophenyl)tetrahydrofuran (194725-15-0)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield: 86.0%

rac-1-(4-bromophenyl)-1,4-butandiol (509083-36-7) → rac-2-(4-bromophenyl)tetrahydrofuran (194725-15-0)

Guidance literature:

With pentafluorophenylboronic acid; oxalic acid; In nitromethane; at 90 ℃; for 6h;

DOI:10.1002/chem.201806057

Reference yield: 75.0%

[S]-1-chloro-4-(4-bromophenyl)-4-butanol → [S]-2-(4-bromophenyl)-tetrahydrofuran (194725-15-0)

Guidance literature:

With NaH; In tetrahydrofuran;

upstream raw materials:

1-(4-bromophenyl)-4-chlorobutan-1-one

4-bromo-benzaldehyde

rac-1-(4-bromophenyl)-1,4-butandiol

bromobenzene