L-Glutamic acid, N-[[5-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]-4-methyl-2-thienyl] carbonyl]-4-fluoro-, bis(1-methylethyl) ester, (4R)-

Base Information

• Chemical Name: L-Glutamic acid, N-[[5-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]-4-methyl-2-thienyl] carbonyl]-4-fluoro-, bis(1-methylethyl) ester, (4R)-
• CAS No.: 194809-43-3
• Molecular Formula: C25H33FN8O5S
• Molecular Weight: 576.652

Synonyms:

Chemical Property of L-Glutamic acid, N-[[5-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]-4-methyl-2-thienyl] carbonyl]-4-fluoro-, bis(1-methylethyl) ester, (4R)-

Chemical Property:

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Safty Information:

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MSDS Files:

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Technology Process of L-Glutamic acid, N-[[5-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]-4-methyl-2-thienyl] carbonyl]-4-fluoro-, bis(1-methylethyl) ester, (4R)-

There total 1 articles about L-Glutamic acid, N-[[5-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]-4-methyl-2-thienyl] carbonyl]-4-fluoro-, bis(1-methylethyl) ester, (4R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-bromomethyl-pteridine-2,4-diamine (59368-16-0) + (2S,4R)-2-Fluoro-4-[(4-methyl-5-methylamino-thiophene-2-carbonyl)-amino]-pentanedioic acid diisopropyl ester (194809-42-2) → (2S,4R)-2-({5-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-4-methyl-thiophene-2-carbonyl}-amino)-4-fluoro-pentanedioic acid diisopropyl ester (194809-43-3)

Guidance literature:

In N,N-dimethyl acetamide; at 50 ℃; for 18h;

DOI:10.1021/jm970085n

upstream raw materials:

6-bromomethyl-pteridine-2,4-diamine

(2S,4R)-2-Fluoro-4-[(4-methyl-5-methylamino-thiophene-2-carbonyl)-amino]-pentanedioic acid diisopropyl ester

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