3-(2-Piperidin-1-yl-vinyl)-pyrido(3,4-e)(1,2,4)triazine

Base Information

• Chemical Name: 3-(2-Piperidin-1-yl-vinyl)-pyrido(3,4-e)(1,2,4)triazine
• CAS No.: 121845-70-3
• Molecular Formula: C13H15 N5
• Molecular Weight: 241.296
• ChEMBL ID: CHEMBL312042
• Mol file: 121845-70-3.mol

Synonyms:121845-70-3;3-(2-Piperidin-1-yl-vinyl)-pyrido(3,4-e)(1,2,4)triazine;3-(2-Piperidin-1-yl-vinyl)-pyrido[3,4-e][1,2,4]triazine;CHEMBL312042;3-[(E)-2-(1-piperidyl)vinyl]pyrido[3,4-e][1,2,4]triazine

Chemical Property of 3-(2-Piperidin-1-yl-vinyl)-pyrido(3,4-e)(1,2,4)triazine

Chemical Property:

• Vapor Pressure: 2.21E-08mmHg at 25°C
• Boiling Point: 452.6°Cat760mmHg
• Flash Point: 227.5°C
• Density: 1.321g/cm³
• XLogP3: 1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 2
• Exact Mass: 241.13274550
• Heavy Atom Count: 18
• Complexity: 287

Purity/Quality:

99% ，98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CCN(CC1)C=CC2=NC3=C(C=CN=C3)N=N2
• Isomeric SMILES: C1CCN(CC1)/C=C/C2=NC3=C(C=CN=C3)N=N2

Technology Process of 3-(2-Piperidin-1-yl-vinyl)-pyrido(3,4-e)(1,2,4)triazine

There total 8 articles about 3-(2-Piperidin-1-yl-vinyl)-pyrido(3,4-e)(1,2,4)triazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

piperidine (110-89-4) + N,N-dimethyl-2-(pyrido<3,4-e>-1,2,4-triazin-3-yl)ethenamine (121845-69-0) → 3-<2-(1-piperidinyl)ethenyl>pyrido<3,4-e>-1,2,4-triazine (121845-70-3)

Guidance literature:

for 20h; Heating;

DOI:10.1021/jm00131a010

Reference yield:

4-hydroxy-3-nitropyridine (5435-54-1) → 3-<2-(1-piperidinyl)ethenyl>pyrido<3,4-e>-1,2,4-triazine (121845-70-3)

Guidance literature:

Multi-step reaction with 7 steps

1: 87 percent / PCl₅, POCl₃ / 6 h / 130 - 140 °C

2: ethanol / 5 h / Heating

3: H₂ / 5percent Pd/C / aq. ethanol / 2327.2 Torr

4: HCl / ethanol / 1.) 25 deg C, 5 h, 2.) reflux, 1.5 h

5: MnO₂, 5 M NaOH / H₂O / 0.83 h / pH 6

6: 41 percent / 2 h / 90 - 100 °C

7: 53 percent / 20 h / Heating

With hydrogenchloride; manganese(IV) oxide; sodium hydroxide; phosphorus pentachloride; hydrogen; trichlorophosphate; palladium on activated charcoal; In ethanol; water;

DOI:10.1021/jm00131a010

Reference yield:

pyridin-4-ol (626-64-2,157061-69-3) → 3-<2-(1-piperidinyl)ethenyl>pyrido<3,4-e>-1,2,4-triazine (121845-70-3)

Guidance literature:

Multi-step reaction with 8 steps

1: 72 percent / HNO₃, H₂SO₄, SO₃ / 1 h / Heating

2: 87 percent / PCl₅, POCl₃ / 6 h / 130 - 140 °C

3: ethanol / 5 h / Heating

4: H₂ / 5percent Pd/C / aq. ethanol / 2327.2 Torr

5: HCl / ethanol / 1.) 25 deg C, 5 h, 2.) reflux, 1.5 h

6: MnO₂, 5 M NaOH / H₂O / 0.83 h / pH 6

7: 41 percent / 2 h / 90 - 100 °C

8: 53 percent / 20 h / Heating

With hydrogenchloride; manganese(IV) oxide; sodium hydroxide; phosphorus pentachloride; sulfuric acid; sulfur trioxide; hydrogen; nitric acid; trichlorophosphate; palladium on activated charcoal; In ethanol; water;

DOI:10.1021/jm00131a010

upstream raw materials:

piperidine

N,N-dimethyl-2-(pyrido<3,4-e>-1,2,4-triazin-3-yl)ethenamine

pyridin-4-ol

3-methyl-pyrido[3,4-e][1,2,4]triazine