3-[4-(2-Oxopyrrolidin-1-yl)phenyl]prop-2-enoic acid

Base Information

Chemical Name:3-[4-(2-Oxopyrrolidin-1-yl)phenyl]prop-2-enoic acid
CAS No.:194928-68-2
Molecular Formula:C13H13NO3
Molecular Weight:231.251
Hs Code.:
European Community (EC) Number:899-222-6
Mol file:194928-68-2.mol

Synonyms:3-[4-(2-oxopyrrolidin-1-yl)phenyl]prop-2-enoic acid;(2E)-3-[4-(2-oxopyrrolidin-1-yl)phenyl]prop-2-enoic acid;194928-68-2;(E)-3-[4-(2-oxopyrrolidin-1-yl)phenyl]prop-2-enoic Acid;160648-06-6;SCHEMBL6965728;AKOS033971178;EN300-25902;EN300-270449;3-[4-(2-oxopyrrolidin-1-yl)phenyl]prop-2-enoicacid;Z2670715795;V5O

Suppliers and Price of 3-[4-(2-Oxopyrrolidin-1-yl)phenyl]prop-2-enoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 3-[4-(2-Oxopyrrolidin-1-yl)phenyl]prop-2-enoic acid

Chemical Property:

XLogP3:1.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:231.08954328
Heavy Atom Count:17
Complexity:330

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CC(=O)N(C1)C2=CC=C(C=C2)C=CC(=O)O
Isomeric SMILES:C1CC(=O)N(C1)C2=CC=C(C=C2)/C=C/C(=O)O

Technology Process of 3-[4-(2-Oxopyrrolidin-1-yl)phenyl]prop-2-enoic acid

There total 4 articles about 3-[4-(2-Oxopyrrolidin-1-yl)phenyl]prop-2-enoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 215258-30-3
ethyl 4-(2-oxo-1-pyrrolidinyl)cinnamate

: 194928-68-2
(E)-4-(2-oxopyrrolidin-1-yl)cinnamic acid

Guidance literature:: With sodium hydroxide; In ethanol; at 60 ℃; for 1h;
DOI:10.1021/jm980214f

Reference yield:

: 5048-82-8,198195-25-4
(E)-ethyl 3-(4-aminophenyl)acrylate

: 194928-68-2
(E)-4-(2-oxopyrrolidin-1-yl)cinnamic acid

Guidance literature:: Multi-step reaction with 3 steps

1: HOBt, WSCD*HCl / dimethylformamide / 2 h

2: 87.8 percent / K₂CO₃ / dimethylformamide / 3 h / 50 °C

3: 1N aq. NaOH / ethanol / 1 h / 60 °C

With sodium hydroxide; WSCD*HCl; potassium carbonate; benzotriazol-1-ol; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm980214f

Reference yield:

: 215258-29-0
ethyl 4-(4-bromobutyramido)cinnamate

: 194928-68-2
(E)-4-(2-oxopyrrolidin-1-yl)cinnamic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 87.8 percent / K₂CO₃ / dimethylformamide / 3 h / 50 °C

2: 1N aq. NaOH / ethanol / 1 h / 60 °C

With sodium hydroxide; potassium carbonate; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm980214f