4-[4-(4-Fluorophenyl)-1-(3-phenylpropyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]-3-butyn-1-ol

Base Information

Chemical Name:4-[4-(4-Fluorophenyl)-1-(3-phenylpropyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]-3-butyn-1-ol
CAS No.:215303-72-3
Molecular Formula:C27H24FN3O
Molecular Weight:425.505
Hs Code.:
UNII:MXN26D3ZUN
DSSTox Substance ID:DTXSID40175867
Nikkaji Number:J1.238.588I
Wikidata:Q72486769
ChEMBL ID:CHEMBL190333
Mol file:215303-72-3.mol

Synonyms:4-(4-(4-fluorophenyl)-1-(3-phenylpropyl)-5-(4-pyridinyl)-1H-imidazol-2-yl)-3-butyn-1-ol;RWJ 67657;RWJ-67657

Suppliers and Price of 4-[4-(4-Fluorophenyl)-1-(3-phenylpropyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]-3-butyn-1-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
RWJ 67657
1mg
$ 262.00

TRC
RWJ-67657
50mg
$ 1320.00

Tocris
RWJ67657 ≥98%(HPLC)
10
$ 194.00

Medical Isotopes, Inc.
RWJ-67657
10 mg
$ 650.00

ChemScene
RWJ-67657 98.23%
10mg
$ 850.00

ChemScene
RWJ-67657 98.23%
5mg
$ 500.00

Cayman Chemical
RWJ 67657 ≥95%
5mg
$ 70.00

Cayman Chemical
RWJ 67657 ≥95%
1mg
$ 35.00

Cayman Chemical
RWJ 67657 ≥95%
10mg
$ 95.00

Cayman Chemical
RWJ 67657 ≥95%
50mg
$ 350.00

Total 16 raw suppliers

Chemical Property of 4-[4-(4-Fluorophenyl)-1-(3-phenylpropyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]-3-butyn-1-ol

Chemical Property:

Vapor Pressure:8.01E-16mmHg at 25°C
Melting Point:124℃
Boiling Point:611.8°Cat760mmHg
PKA:14.37±0.10(Predicted)
Flash Point:323.8°C
PSA：50.94000
Density:1.14g/cm³
LogP:5.11790
Storage Temp.:Store at RT
Solubility.:≤10mg/ml in ethanol;5mg/ml in DMSO;2mg/ml in dimethyl formamide
XLogP3:4.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:8
Exact Mass:425.19034056
Heavy Atom Count:32
Complexity:611

Purity/Quality:

99%, ^*data from raw suppliers

RWJ 67657 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)CCCN2C(=NC(=C2C3=CC=NC=C3)C4=CC=C(C=C4)F)C#CCCO
Uses RWJ-67657 is a p38 mitogen-activated protein-kinase (p38MAPK) inhibitor. Studies show that RWJ-67657 might provide a useful tool to intervene in the deranged immune response in sepsis and other inflam matory diseases. RWJ 67657 has been shown to inhibit chemokine production and E-selectin expression in activated endothelial cells, RWJ-67657 is a p38 mitogen-activated protein-kinase (p38MAPK) inhibitor. Studies show that RWJ-67657 might provide a useful tool to intervene in the deranged immune response in sepsis and other inflammatory diseases. RWJ 67657 has been shown to inhibit chemokine production and E-selectin expression in activated endothelial cells,

Technology Process of 4-[4-(4-Fluorophenyl)-1-(3-phenylpropyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]-3-butyn-1-ol

There total 2 articles about 4-[4-(4-Fluorophenyl)-1-(3-phenylpropyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]-3-butyn-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: