Technology Process of Phosphonic acid, [3-(phenylmethoxy)cyclobutyl]-, diethyl ester
There total 7 articles about Phosphonic acid, [3-(phenylmethoxy)cyclobutyl]-, diethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
disodium hydrogenphosphate; sodium amalgam;
In
tetrahydrofuran; methanol;
at 0 ℃;
for 2h;
DOI:10.1016/S0040-4020(97)00682-0
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1.) nBuLi / 1.) THF, hexane, -78 deg C, 30 min, 2.) -78 deg C, 1 h; 0 deg C, 1 h
2: m-CPBA / CH2Cl2 / 16 h / 40 °C
3: nBu4NI, BF3*OEt2 / CH2Cl2 / 0 - 20 °C
4: 340 mg / TfOH / diethyl ether / 16 h / Ambient temperature
5: 52 percent / KHMDS / tetrahydrofuran; toluene / 1.) -78 deg C, 30 min, 2.) 0 deg C, 1 h, 3.) room temperature, 3 h
6: 90 percent / 2percent Na(Hg), Na2HPO4 / tetrahydrofuran; methanol / 2 h / 0 °C
With
disodium hydrogenphosphate; n-butyllithium; sodium amalgam; trifluorormethanesulfonic acid; boron trifluoride diethyl etherate; tetra-(n-butyl)ammonium iodide; potassium hexamethylsilazane; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; toluene;
DOI:10.1016/S0040-4020(97)00682-0
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 340 mg / TfOH / diethyl ether / 16 h / Ambient temperature
2: 52 percent / KHMDS / tetrahydrofuran; toluene / 1.) -78 deg C, 30 min, 2.) 0 deg C, 1 h, 3.) room temperature, 3 h
3: 90 percent / 2percent Na(Hg), Na2HPO4 / tetrahydrofuran; methanol / 2 h / 0 °C
With
disodium hydrogenphosphate; sodium amalgam; trifluorormethanesulfonic acid; potassium hexamethylsilazane;
In
tetrahydrofuran; methanol; diethyl ether; toluene;
DOI:10.1016/S0040-4020(97)00682-0
