2-BROMO-3-PHENYL-PROPIONIC ACID

Base Information

• Chemical Name: 2-BROMO-3-PHENYL-PROPIONIC ACID
• CAS No.: 16503-53-0
• Molecular Formula: C9H9 Br O2
• Molecular Weight: 229.073
• Mol file: 16503-53-0.mol

Synonyms:Hydrocinnamicacid, a-bromo- (6CI,8CI);2-Bromo-3-phenylpropionic acid;DL-a-Bromo-b-phenylpropionicacid;

Chemical Property of 2-BROMO-3-PHENYL-PROPIONIC ACID

Chemical Property:

• Vapor Pressure: 0.000461mmHg at 25°C
• Melting Point: 52°C
• Refractive Index: 1.591
• Boiling Point: 301.6°Cat760mmHg
• PKA: 2.82±0.10(Predicted)
• Flash Point: 136.2°C
• PSA: 37.30000
• Density: 1.558g/cm³
• LogP: 2.07720
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2-Bromo-3-phenyl-propionicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-BROMO-3-PHENYL-PROPIONIC ACID

There total 46 articles about 2-BROMO-3-PHENYL-PROPIONIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethane-1,2-diaminium bis[(2R)-2-bromo-3-phenylpropanoate] → (S)-(alpha)-bromobenzenepropanoic acid (42990-55-6,35016-63-8,42990-49-8,16503-53-0)

Guidance literature:

With hydrogenchloride; In di-isopropyl ether; water; at 20 ℃; for 0.5h; pH=1.5 - 6.7;

Reference yield: 98.0%

L-phenylalanine (63-91-2,25191-15-5,658-69-5,67675-33-6) → 2-bromo-3-phenylpropanoic acid (16503-53-0)

Guidance literature:

With hydrogen bromide; sodium nitrite; In water; at 0 - 20 ℃; for 2.5h;

DOI:10.1021/ja510603w

Reference yield: 92.7%

D-(R)-phenylalanine (673-06-3,25191-15-5,658-69-5,67675-33-6) → (S)-(alpha)-bromobenzenepropanoic acid (42990-55-6,35016-63-8,42990-49-8,16503-53-0)

Guidance literature:

D-(R)-phenylalanine; With hydrogen bromide; In water; toluene; at -5 - 15 ℃; for 5h;

With sodium nitrite; In water; toluene; at -6 - 15 ℃; for 6h;

upstream raw materials:

2-chloro-3-phenylpropionitrile

benzyl-bromo-malonic acid

Phenylalanine

2-chloro-3-phenylpropionic acid

Downstream raw materials:

3-phenyl-2-piperidino-propionic acid

N-propyl-phenylalanine

2-ethoxythiocarbonylmercapto-3-phenyl-propionic acid

Cinnamic acid