Carbamic acid, [1,1-dimethyl-2-oxo-2-[[(3R)-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin- 3-yl]amino]ethyl]-, phenylmethyl ester

Base Information

• Chemical Name: Carbamic acid, [1,1-dimethyl-2-oxo-2-[[(3R)-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin- 3-yl]amino]ethyl]-, phenylmethyl ester
• CAS No.: 195248-05-6
• Molecular Formula: C22H25N3O4
• Molecular Weight: 395.458
• Mol file: 195248-05-6.mol

Synonyms:

Chemical Property of Carbamic acid, [1,1-dimethyl-2-oxo-2-[[(3R)-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin- 3-yl]amino]ethyl]-, phenylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Carbamic acid, [1,1-dimethyl-2-oxo-2-[[(3R)-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin- 3-yl]amino]ethyl]-, phenylmethyl ester

There total 2 articles about Carbamic acid, [1,1-dimethyl-2-oxo-2-[[(3R)-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin- 3-yl]amino]ethyl]-, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Z-Aib-OH (15030-72-5) + (R)-3-amino-2,3,4,5-tetrahydro-1H-[1]-benzazepin-2-one (137036-55-6) → 2-benzyloxycarbonylamino-2-methyl-N-[2,3,4,5-tetrahydro-2-oxo-1H-benzazepin-3(R)-yl]propanamide (195248-05-6)

Guidance literature:

With pyridine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; In dichloromethane; for 2h; Ambient temperature;

DOI:10.1021/jm970816j

Reference yield:

benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate (128625-52-5) → 2-benzyloxycarbonylamino-2-methyl-N-[2,3,4,5-tetrahydro-2-oxo-1H-benzazepin-3(R)-yl]propanamide (195248-05-6)

Guidance literature:

Reference yield:

2-benzyloxycarbonylamino-2-methyl-N-[2,3,4,5-tetrahydro-2-oxo-1H-benzazepin-3(R)-yl]propanamide (195248-05-6) → 2-Amino-N-((R)-1-{2'-[(3-ethyl-ureido)-methyl]-biphenyl-4-ylmethyl}-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl)-2-methyl-propionamide

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) NaH / 1.) DMF, 15 min, 2.) DMF, 0 deg C, 15 min

2: anisole / CH₂Cl₂ / 1.5 h / Ambient temperature

3: Et₃N / CH₂Cl₂ / 0.5 h / Ambient temperature

4: H₂ / Pd(OH)2 / methanol / 2 h / 760 Torr

With hydrogen; sodium hydride; methoxybenzene; triethylamine; palladium dihydroxide; In methanol; dichloromethane;

DOI:10.1021/jm970816j

upstream raw materials:

Z-Aib-OH

(R)-3-amino-2,3,4,5-tetrahydro-1H-[1]-benzazepin-2-one

benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate

Downstream raw materials:

(1-{(R)-1-[2'-(tert-Butoxycarbonylamino-methyl)-biphenyl-4-ylmethyl]-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-ylcarbamoyl}-1-methyl-ethyl)-carbamic acid benzyl ester

{1-Methyl-1-[(R)-2-oxo-1-(2'-ureidomethyl-biphenyl-4-ylmethyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-ylcarbamoyl]-ethyl}-carbamic acid benzyl ester

[1-Methyl-1-((R)-1-{2'-[(3-methyl-ureido)-methyl]-biphenyl-4-ylmethyl}-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-ylcarbamoyl)-ethyl]-carbamic acid benzyl ester

(1-{(R)-1-[2'-(3,3-Dimethyl-ureidomethyl)-biphenyl-4-ylmethyl]-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-ylcarbamoyl}-1-methyl-ethyl)-carbamic acid benzyl ester