Filipin III

Base Information

• Chemical Name: Filipin III
• CAS No.: 11078-21-0
• Molecular Formula: Unspecified
• Molecular Weight: 654.82842
• Hs Code.: 2941900000
• European Community (EC) Number: 631-260-9,637-175-3
• Nikkaji Number: J755.176B
• Wikipedia: Filipin
• Wikidata: Q2073868
• NCI Thesaurus Code: C80959
• Metabolomics Workbench ID: 129556
• ChEMBL ID: CHEMBL252059
• Mol file: 11078-21-0.mol

Synonyms:Desoxylagosin;Filimarisin;Filipin;Filipin I;Filipin II;Filipin III;Filipin IV;NSC 3364;NSC-3364;NSC3364;U 5956;U-5956;U5956

Chemical Property of Filipin III

Chemical Property:

• Appearance/Colour: yellow powder
• Melting Point: 195-205°
• Boiling Point: 913.9oC at 760 mmHg
• Flash Point: 279.3oC
• PSA: 208.37000
• Density: 1.161 g/cm3
• LogP: 1.88800
• Storage Temp.: −20°C
• Solubility.: methanol: 10 mg/mL, clear, very dark yellow
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 9
• Hydrogen Bond Acceptor Count: 11
• Rotatable Bond Count: 5
• Exact Mass: 654.39791266
• Heavy Atom Count: 46
• Complexity: 991

Purity/Quality:

98%,99%, ^*data from raw suppliers

Filipin complex from Streptomyces filipinensis ≥70% (UV) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi,Xn
• Hazard Codes: Xn,Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CCCCCC(C1C(CC(CC(CC(CC(CC(CC(C(=CC=CC=CC=CC=CC(C(OC1=O)C)O)C)O)O)O)O)O)O)O)O
• Isomeric SMILES: CCCCC[C@H]([C@@H]1[C@H](C[C@H](C[C@H](C[C@H](C[C@H](C[C@H](C[C@@H](/C(=C/C=C/C=C/C=C/C=C/[C@@H]([C@H](OC1=O)C)O)/C)O)O)O)O)O)O)O)O
• Uses: Filipin complex comprises a family of pentaene macrocyclic lactones first isolated from Streptomyces filipinensis and reported by researchers at Upjohn in 1955. Filipin complex consists of four analogues, with filipin III comprising the bulk (>70%) of the complex. Filipin complex is a potent broad spectrum antifungal agent that also exhibits antitumor and antiviral activities. Filipin complex acts by binding cell membrane sterols, disrupting membrane integrity. Filipin complex from Streptomyces filipinensis has been used as a profluorescence probe to detect the free cholesterol in cell.