Benzo[b]thiophene, 3,5-dimethyl-, 1,1-dioxide

Base Information

• Chemical Name: Benzo[b]thiophene, 3,5-dimethyl-, 1,1-dioxide
• CAS No.: 1964-40-5
• Molecular Formula: C10H10O2S
• Mol file: 1964-40-5.mol

Synonyms:

Chemical Property of Benzo[b]thiophene, 3,5-dimethyl-, 1,1-dioxide

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzo[b]thiophene, 3,5-dimethyl-, 1,1-dioxide

There total 4 articles about Benzo[b]thiophene, 3,5-dimethyl-, 1,1-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

3,5-dimethylbenzothiophene (1964-45-0) → 3,5-dimethylbenzo[b]thiophene 1,1-dioxide (1964-40-5)

Guidance literature:

With dihydrogen peroxide; trifluoroacetic acid; In dichloromethane; at 20 ℃;

DOI:10.1021/acs.orglett.0c04114

Reference yield:

3,5-dibromobenzothiophene (1423-62-7) → 3,5-dimethylbenzo[b]thiophene 1,1-dioxide (1964-40-5)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate monohydrate / 1,4-dioxane / 100 °C / Sealed tube

2: trifluoroacetic acid; dihydrogen peroxide / dichloromethane / 20 °C

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate monohydrate; dihydrogen peroxide; palladium diacetate; trifluoroacetic acid; In 1,4-dioxane; dichloromethane;

DOI:10.1021/acs.orglett.0c04114

Reference yield:

5-bromobenzo[b]thiophene (4923-87-9) → 3,5-dimethylbenzo[b]thiophene 1,1-dioxide (1964-40-5)

Guidance literature:

Multi-step reaction with 3 steps

1: N-Bromosuccinimide; acetic acid / chloroform / 6 h / 50 °C

2: palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate monohydrate / 1,4-dioxane / 100 °C / Sealed tube

3: trifluoroacetic acid; dihydrogen peroxide / dichloromethane / 20 °C

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; N-Bromosuccinimide; potassium phosphate monohydrate; dihydrogen peroxide; palladium diacetate; acetic acid; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; chloroform;

DOI:10.1021/acs.orglett.0c04114

upstream raw materials:

3,5-dibromobenzothiophene

3,5-dimethylbenzothiophene

5-bromobenzo[b]thiophene