L 778,123

Base Information

Chemical Name:L 778,123
CAS No.:197853-31-9
Molecular Formula:C22H20ClN5O
Molecular Weight:405.88000
Hs Code.:
Mol file:197853-31-9.mol

Synonyms:

Suppliers and Price of L 778,123

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 16 raw suppliers

Chemical Property of L 778,123

Chemical Property:

Boiling Point:712.6±60.0 °C(Predicted)
PKA:6.09±0.13(Predicted)
PSA：65.16000
Density:1.29±0.1 g/cm3(Predicted)
LogP:3.30818

Purity/Quality:: 99%, ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of L 778,123

There total 6 articles about L 778,123 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 183500-37-0
4-[(5-formyl-1H-imidazol-1-yl)methyl]benzonitrile

: N-(2-aminoethyl)-N-[(carbomethoxy)-methyl]-3-chloroaniline hydrochloride

: 197853-31-9
4-(3-Chlorophenyl)-1-[1-(4-cyanobenzyl)-5-imidazolylmethyl]-2-piperazinone

Guidance literature:: With 4 A molecular sieve; sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 0 - 20 ℃;
DOI:10.1016/S0960-894X(00)00710-1

Reference yield:

: 141-85-5
3-chloroaniline hydrochloride

: 197853-31-9
4-(3-Chlorophenyl)-1-[1-(4-cyanobenzyl)-5-imidazolylmethyl]-2-piperazinone

Guidance literature:: Multi-step reaction with 5 steps

1: various solvent(s) / 160 °C

2: aq. NaHCO₃ / tetrahydrofuran

3: 45 percent / K₂CO₃ / dimethylformamide / 60 °C

4: 100 percent / HCl / ethyl acetate / 0 °C

5: 45 percent / Na(AcO)3BH; 4 A molecular sieves / 1,2-dichloro-ethane / 0 - 20 °C

With hydrogenchloride; 4 A molecular sieve; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; potassium carbonate; In tetrahydrofuran; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(00)00710-1

Reference yield:

: 14088-83-6
N-(3-chlorophenyl)-1,2-diaminoethane

: 197853-31-9
4-(3-Chlorophenyl)-1-[1-(4-cyanobenzyl)-5-imidazolylmethyl]-2-piperazinone

Guidance literature:: Multi-step reaction with 4 steps

1: aq. NaHCO₃ / tetrahydrofuran

2: 45 percent / K₂CO₃ / dimethylformamide / 60 °C

3: 100 percent / HCl / ethyl acetate / 0 °C

4: 45 percent / Na(AcO)3BH; 4 A molecular sieves / 1,2-dichloro-ethane / 0 - 20 °C

With hydrogenchloride; 4 A molecular sieve; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; potassium carbonate; In tetrahydrofuran; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(00)00710-1