4-amino-N-(3-methoxyphenyl)benzenesulfonamide

Base Information

• Chemical Name: 4-amino-N-(3-methoxyphenyl)benzenesulfonamide
• CAS No.: 19837-79-7
• Molecular Formula: C13H14N2O3S
• Molecular Weight: 278.332
• Hs Code.: 2935009090
• ChEMBL ID: CHEMBL4566058
• DSSTox Substance ID: DTXSID70588628
• Wikidata: Q82481419
• Mol file: 19837-79-7.mol

Synonyms:4-amino-N-(3-methoxyphenyl)benzenesulfonamide;19837-79-7;4-Amino-N-(3-methoxyphenyl)benzene-1-sulfonamide;SCHEMBL2242644;CHEMBL4566058;DTXSID70588628;MFCD03002130;STK500389;AKOS000149726;MCULE-3846041026;SB81385;TS-00961;E89172

Chemical Property of 4-amino-N-(3-methoxyphenyl)benzenesulfonamide

Chemical Property:

• PSA: 89.80000
• LogP: 3.81320
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 4
• Exact Mass: 278.07251349
• Heavy Atom Count: 19
• Complexity: 372

Purity/Quality:

98%min ^*data from raw suppliers

4-Amino-N-(3-methoxyphenyl)benzenesulfonamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC(=C1)NS(=O)(=O)C2=CC=C(C=C2)N

Technology Process of 4-amino-N-(3-methoxyphenyl)benzenesulfonamide

There total 7 articles about 4-amino-N-(3-methoxyphenyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.8%

N-(3-methoxyphenyl)-4-nitrobenzenesulfonamide (16936-99-5) → 4-amino-N-(3-methoxyphenyl)-benzenesulfonamide (19837-79-7)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; ethyl acetate; at 20 ℃; for 8h;

Reference yield: 74.5%

N-{4-[(3-methoxyphenyl)sulfamoyl]phenyl}acetamide (19837-96-8) → 4-amino-N-(3-methoxyphenyl)-benzenesulfonamide (19837-79-7)

Guidance literature:

With hydrogenchloride; In ethanol; at 70 ℃;

DOI:10.1039/d1ce00869b

Reference yield:

m-Anisidine (536-90-3,918666-97-4) → 4-amino-N-(3-methoxyphenyl)-benzenesulfonamide (19837-79-7)

Guidance literature:

Multi-step reaction with 2 steps

1: water; sodium acetate

2: aqueous hydrochloric acid

With hydrogenchloride; water; sodium acetate;

upstream raw materials:

N-{4-[(3-methoxyphenyl)sulfamoyl]phenyl}acetamide

m-Anisidine

p-acetylaminobenzenesulfonyl chloride

N-(3-methoxyphenyl)-4-nitrobenzenesulfonamide

Downstream raw materials:

1,3-dihydro-5-1-(m-methoxyphenyl)-p-sulphamylbenzeneazo>-1-(2'-naphthyl)-3-phenyl-2-thioxo-2H,5H-pyrimidine-4,6-dione

1,3-dihydro-5-1-(m-methoxyphenyl)-p-sulphamylbenzeneazo>-1-(2'-naphthyl)-3-(p-tolyl)-2-thioxo-2H,5H-pyrimidine-4,6-dione

4-(3-chloro-1,4-dioxo-1,4-dihydro-naphthalen-2-ylamino)-N-(3-methoxyphenyl)-benzenesulfonamide