3-(5-fluoro-indol-3-yl)-pyrrolidine-2,5-dione

Base Information

Chemical Name:3-(5-fluoro-indol-3-yl)-pyrrolidine-2,5-dione
CAS No.:198474-05-4
Molecular Formula:C₁₂H₉FN₂O₂
Molecular Weight:232.214
Hs Code.:
Mol file:198474-05-4.mol

Synonyms:

Suppliers and Price of 3-(5-fluoro-indol-3-yl)-pyrrolidine-2,5-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
PF-06840003
500mg
$ 380.00

TRC
PF-06840003
100mg
$ 90.00

TRC
PF-06840003
1g
$ 735.00

DC Chemicals
PF06840003 >98%
1 g
$ 1450.00

DC Chemicals
PF06840003 >98%
250 mg
$ 700.00

CSNpharm
PF-06840003
5mg
$ 60.00

CSNpharm
PF-06840003
100mg
$ 298.00

Crysdot
PF-06840003 95+%
50mg
$ 683.00

Crysdot
PF-06840003 95+%
100mg
$ 1140.00

ChemScene
PF-06840003 99.79%
50mg
$ 220.00

Total 25 raw suppliers

Chemical Property of 3-(5-fluoro-indol-3-yl)-pyrrolidine-2,5-dione

Chemical Property:

PSA：65.45000
LogP:1.71300
Storage Temp.:Inert atmosphere,Room Temperature
Solubility.:Soluble in DMSO (up to at least 25 mg/ml)

Purity/Quality:

99%, ^*data from raw suppliers

PF-06840003 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Description PF-06840003 (198474-05-4) is a potent (IC50?= 150 and 410 nM via two methods) and selective inhibitor of Indoleamine-2,3-dioxygenase (IDO1).1?In mice with syngeneic tumor grafts, it reduced intratumoral kynurenine levels by over 80%, inhibited tumor growth as monotherapy, and increased the efficacy of anti-PD-L1 therapy.2?PF-06840003 treatment combined with GM-CSF-secreting allogenic pancreatic tumor cell vaccine (GVAX) resulted in increased antitumor efficacy in a murine model of pancreatic ductal adenocarcinoma.3
Uses PF-06840003 is a potential clinical candidate as a novel and selective Indoleamine 2,3-dioxygenase inhibitor. Highly selective and orally bioavailable IDO-1 inhibitor.

Technology Process of 3-(5-fluoro-indol-3-yl)-pyrrolidine-2,5-dione

There total 2 articles about 3-(5-fluoro-indol-3-yl)-pyrrolidine-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%