3-Chloro-4-(2-pyridinylamino)hydratropic acid

Base Information

Chemical Name:3-Chloro-4-(2-pyridinylamino)hydratropic acid
CAS No.:83528-38-5
Molecular Formula:C14H13ClN2O2
Molecular Weight:276.7182
Hs Code.:
DSSTox Substance ID:DTXSID701003519
Nikkaji Number:J59.870D
ChEMBL ID:CHEMBL72673

Synonyms:83528-38-5;BRN 6218156;3-Chloro-4-(2-pyridinylamino)hydratropic acid;Benzeneacetic acid, 3-chloro-alpha-methyl-4-(2-pyridinylamino)-;Hydratropic acid, 3-chloro-4-(2-pyridinylamino)-;CHEMBL72673;SCHEMBL11277453;DTXSID701003519;LS-76352;2-[4-(2-Pyridinylamino)-3-chlorophenyl]propionic acid;2-{3-Chloro-4-[(pyridin-2-yl)amino]phenyl}propanoic acid

Suppliers and Price of 3-Chloro-4-(2-pyridinylamino)hydratropic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 3-Chloro-4-(2-pyridinylamino)hydratropic acid

Chemical Property:

Vapor Pressure:7.19E-08mmHg at 25°C
Boiling Point:421.9°Cat760mmHg
Flash Point:208.9°C
Density:1.347g/cm³
XLogP3:3.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:276.0665554
Heavy Atom Count:19
Complexity:314

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C1=CC(=C(C=C1)NC2=CC=CC=N2)Cl)C(=O)O

Technology Process of 3-Chloro-4-(2-pyridinylamino)hydratropic acid

There total 6 articles about 3-Chloro-4-(2-pyridinylamino)hydratropic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 83528-20-5
2-[3-Chloro-4-(pyridin-2-ylamino)-phenyl]-propionic acid methyl ester

: 83528-38-5
2-[3-chloro-4-(2'-pyridylamino)phenyl]propionic acid

Guidance literature:: With sodium hydroxide; In methanol; for 1h; Ambient temperature;
DOI:10.1021/jm00356a019

Reference yield:

: 611-06-3
2,4-dichloronitrobenzene

: 83528-38-5
2-[3-chloro-4-(2'-pyridylamino)phenyl]propionic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) NaH / 1.) DMF, 50 deg C, 20 min, 2.) DMF, 100 deg C, 2 h

2: NaOH / dimethylformamide; methanol; H₂O / 1 h / 50 °C

3: concd. H₂SO₄ / 3 h / Heating

4: 52 percent / H₂ / 5percent Pd/C / ethanol / 760 Torr

5: 160 - 170 °C

6: 46 percent / 10percent NaOH / methanol / 1 h / Ambient temperature

With sodium hydroxide; sulfuric acid; hydrogen; sodium hydride; palladium on activated charcoal; In methanol; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00356a019

Reference yield:

: 26039-74-7
Diethyl 2-(3-chloro-4-nitrophenyl)-2-methylmalonate

: 83528-38-5
2-[3-chloro-4-(2'-pyridylamino)phenyl]propionic acid

Guidance literature:: Multi-step reaction with 5 steps

1: NaOH / dimethylformamide; methanol; H₂O / 1 h / 50 °C

2: concd. H₂SO₄ / 3 h / Heating

3: 52 percent / H₂ / 5percent Pd/C / ethanol / 760 Torr

4: 160 - 170 °C

5: 46 percent / 10percent NaOH / methanol / 1 h / Ambient temperature

With sodium hydroxide; sulfuric acid; hydrogen; palladium on activated charcoal; In methanol; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00356a019