4-(5-BROMOPYRIDIN-3-YL)MORPHOLINE

Base Information

• Chemical Name: 4-(5-BROMOPYRIDIN-3-YL)MORPHOLINE
• CAS No.: 200064-13-7
• Molecular Formula: C₉H₁₁BrN₂O
• Molecular Weight: 243.103
• Hs Code.: 2934999090
• Mol file: 200064-13-7.mol

Synonyms:4-(5-bromo-3-pyridinyl)morpholine;4-(5-bromopyridin-3-yl) morpholine;3-Bromo-5-morpholinopyridine;Morpholine,4-(5-bromo-3-pyridinyl);5-bromo-3-(morpholin-4-yl)pyridine;

Chemical Property of 4-(5-BROMOPYRIDIN-3-YL)MORPHOLINE

Chemical Property:

• Melting Point: 87.9-89.5 °C
• Boiling Point: 354.4±42.0 °C(Predicted)
• PKA: 4.45±0.22(Predicted)
• PSA: 25.36000
• Density: 1.499±0.06 g/cm3(Predicted)
• LogP: 1.74570
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

3-Bromo-5-morpholinopyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(5-BROMOPYRIDIN-3-YL)MORPHOLINE

There total 8 articles about 4-(5-BROMOPYRIDIN-3-YL)MORPHOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

morpholine (110-91-8,99108-56-2) + 3,5-dibromopyridine (625-92-3) → 4-(5-bromopyridin-3-yl) morpholine (200064-13-7)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; In toluene; at 115 ℃; for 18h; Inert atmosphere;

DOI:10.1021/jm900249k

Reference yield: 71.0%

lithium morpholide (37828-58-3) + 3,5-dibromopyridine (625-92-3) → 4-(5-bromopyridin-3-yl) morpholine (200064-13-7)

Guidance literature:

3,5-dibromopyridine; With TurboGrignard; In tetrahydrofuran; at 0 - 25 ℃; for 1.16667h; Inert atmosphere;

With zinc(II) chloride; In tetrahydrofuran; at 0 ℃; for 0.5h; Inert atmosphere;

lithium morpholide; Further stages;

DOI:10.1021/ol902056j

Reference yield: 64.9%

→ 4-(5-bromopyridin-3-yl) morpholine (200064-13-7)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 120 ℃;

upstream raw materials:

morpholine

3,5-dibromopyridine

lithium morpholide

C₁₂H₁₉BrN₂O₂Si

Downstream raw materials:

3-chloro-N-[6-methyl-3-[5-(4-morpholinyl)-3-pyridinyl]-2-(1H-pyrazol-4-yl)thieno[2,3-b]pyridin-4-yl]benzenesulfonamide

4-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2yl)-3-pyridinyl]morpholine

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