7-DIETHYLAMINO-3-((((2-MALEIMIDYL)ETHYL)AMINO) CARBONYL)COUMARIN

Base Information

• Chemical Name: 7-DIETHYLAMINO-3-((((2-MALEIMIDYL)ETHYL)AMINO) CARBONYL)COUMARIN
• CAS No.: 156571-46-9
• Molecular Formula: C₂₀H₂₁N₃O₅
• Molecular Weight: 383.404
• Mol file: 156571-46-9.mol

Synonyms:MDCC;N-[2-(1-Maleimidyl)ethyl]-7-diethylaminocoumarin-3-carboxamide

Chemical Property of 7-DIETHYLAMINO-3-((((2-MALEIMIDYL)ETHYL)AMINO) CARBONYL)COUMARIN

Chemical Property:

• Vapor Pressure: 6.42E-19mmHg at 25°C
• Boiling Point: 690.5°Cat760mmHg
• Flash Point: 371.4°C
• PSA: 99.93000
• Density: 1.346g/cm³
• LogP: 1.62280

Purity/Quality:

98%Min ^*data from raw suppliers

7-Diethylamino-3-[N-(2-maleimidoethyl)carbamoyl]coumarin ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: Thiol-reactive fluorescent probe for protein labeling. MDCC(7-Diethylamino-3-[N-(2-maleimidoethyl)carbamoyl]coumarin) has been used for preparing specific probes for inorganic phosphate. 7-Diethylamino-3-[N-(2-maleimidoethyl)carbamoyl]coumarin is a thiol-reactive probe used for protein labeling.

Technology Process of 7-DIETHYLAMINO-3-((((2-MALEIMIDYL)ETHYL)AMINO) CARBONYL)COUMARIN

There total 7 articles about 7-DIETHYLAMINO-3-((((2-MALEIMIDYL)ETHYL)AMINO) CARBONYL)COUMARIN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(Z)-3-{2-[(7-Diethylamino-2-oxo-2H-chromene-3-carbonyl)-amino]-ethylcarbamoyl}-acrylic acid → 7-diethylamino-N-(2-maleimidoethyl)-2-oxo-2H-chromene-3-carboxamide (156571-46-9)

Guidance literature:

With cobalt naphthenate; acetic anhydride; In N,N-dimethyl acetamide; at 70 - 80 ℃; for 2h; Yield given;

Reference yield:

4-(Diethylamino)salicylaldehyde (17754-90-4) → 7-diethylamino-N-(2-maleimidoethyl)-2-oxo-2H-chromene-3-carboxamide (156571-46-9)

Guidance literature:

Multi-step reaction with 7 steps

1: 40 percent / piperidine / ethanol / 4 h / Heating

2: 90 percent / aq. NaOH / methanol / 0.08 h / Heating

3: tributylamine / dimethylformamide / 0.5 h / 0 - 5 °C

4: dimethylformamide / 3 h / Ambient temperature

5: trifluoroacetic acid / 1 h / Ambient temperature

6: N,N-dimethyl-acetamide / 0.33 h / 20 - 60 °C

7: cobalt naphthenate, acetic anhydride / N,N-dimethyl-acetamide / 2 h / 70 - 80 °C

With piperidine; sodium hydroxide; cobalt naphthenate; tributyl-amine; acetic anhydride; trifluoroacetic acid; In methanol; ethanol; N,N-dimethyl acetamide; N,N-dimethyl-formamide;

Reference yield:

ethyl 7-diethylaminocoumarin-3-carboxylate (28705-46-6) → 7-diethylamino-N-(2-maleimidoethyl)-2-oxo-2H-chromene-3-carboxamide (156571-46-9)

Guidance literature:

Multi-step reaction with 6 steps

1: 90 percent / aq. NaOH / methanol / 0.08 h / Heating

2: tributylamine / dimethylformamide / 0.5 h / 0 - 5 °C

3: dimethylformamide / 3 h / Ambient temperature

4: trifluoroacetic acid / 1 h / Ambient temperature

5: N,N-dimethyl-acetamide / 0.33 h / 20 - 60 °C

6: cobalt naphthenate, acetic anhydride / N,N-dimethyl-acetamide / 2 h / 70 - 80 °C

With sodium hydroxide; cobalt naphthenate; tributyl-amine; acetic anhydride; trifluoroacetic acid; In methanol; N,N-dimethyl acetamide; N,N-dimethyl-formamide;

upstream raw materials:

4-(Diethylamino)salicylaldehyde

ethyl 7-diethylaminocoumarin-3-carboxylate

7-(diethylamino)coumarin-3-carboxylic acid

tert-butyl N-<2-(7-diethylamino-2-oxo-2H-chromene-3-carboxamido)ethyl>carbamate

Downstream raw materials:

H-SQWF-NH₂

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