1-Oxa-7-azaspiro[4.5]dec-3-ene-7-carboxylic acid, 6-phenyl-3-[2-(phenylmethoxy)-5-(trifluoromethoxy)phenyl]-, 1,1-dimethylethyl ester, (5R,6S)-

Base Information

Chemical Name:1-Oxa-7-azaspiro[4.5]dec-3-ene-7-carboxylic acid, 6-phenyl-3-[2-(phenylmethoxy)-5-(trifluoromethoxy)phenyl]-, 1,1-dimethylethyl ester, (5R,6S)-
CAS No.:200953-37-3
Molecular Formula:C33H34F3NO5
Molecular Weight:581.632
Hs Code.:

1-Oxa-7-azaspiro[4.5]dec-3-ene-7-carboxylic acid,
6-phenyl-3-[2-(phenylmethoxy)-5-(trifluoromethoxy)phenyl]-,
1,1-dimethylethyl ester, (5R,6S)-

Synonyms:

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Chemical Property of 1-Oxa-7-azaspiro[4.5]dec-3-ene-7-carboxylic acid, 6-phenyl-3-[2-(phenylmethoxy)-5-(trifluoromethoxy)phenyl]-, 1,1-dimethylethyl ester, (5R,6S)-

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MSDS Files:: SDS file from LookChem

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Technology Process of 1-Oxa-7-azaspiro[4.5]dec-3-ene-7-carboxylic acid, 6-phenyl-3-[2-(phenylmethoxy)-5-(trifluoromethoxy)phenyl]-, 1,1-dimethylethyl ester, (5R,6S)-

There total 3 articles about 1-Oxa-7-azaspiro[4.5]dec-3-ene-7-carboxylic acid, 6-phenyl-3-[2-(phenylmethoxy)-5-(trifluoromethoxy)phenyl]-, 1,1-dimethylethyl ester, (5R,6S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: (5R,6S)-3-tributylstannyl-6-phenyl-1-oxa-7-(tert-butoxycarbonyl)azaspiro[4.5]dec-3-ene

: 143582-95-0
4-benzyloxy-3-bromophenyl trifluoromethyl ether

: 200953-37-3
(5R,6S)-3-(2-benzyloxy-5-(trifluorometoxy)phenyl)-6-phenyl-1-oxa-7-(tert-butoxycarbonyl)azaspiro[4.5]dec-3-ene

Guidance literature:: With lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene; for 48h; Heating;
DOI:10.1021/ol006944a

Reference yield:

: 200956-13-4
2-Bromo-4-(trifluoromethoxy)phenol

: 200953-37-3
(5R,6S)-3-(2-benzyloxy-5-(trifluorometoxy)phenyl)-6-phenyl-1-oxa-7-(tert-butoxycarbonyl)azaspiro[4.5]dec-3-ene

Guidance literature:: Multi-step reaction with 2 steps

1: 96 percent / K₂CO₃ / dimethylformamide / 15 h / 20 °C

2: 70 percent / LiCl / Pd(PPh₃)4 / toluene / 48 h / Heating

With potassium carbonate; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; toluene;
DOI:10.1021/ol006944a

Reference yield:

: 828-27-3
4-Trifluoromethoxyphenol

: 200953-37-3
(5R,6S)-3-(2-benzyloxy-5-(trifluorometoxy)phenyl)-6-phenyl-1-oxa-7-(tert-butoxycarbonyl)azaspiro[4.5]dec-3-ene

Guidance literature:: Multi-step reaction with 3 steps

1: Br₂ / CHCl₃ / 3 h / 0 - 20 °C

2: 96 percent / K₂CO₃ / dimethylformamide / 15 h / 20 °C

3: 70 percent / LiCl / Pd(PPh₃)4 / toluene / 48 h / Heating

With bromine; potassium carbonate; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In chloroform; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ol006944a