1-Oxa-7-azaspiro[4.5]decane-7-carboxylic acid, 6-phenyl-3-[2-(phenylmethoxy)-5-(trifluoromethoxy)phenyl]-, 1,1-dimethylethyl ester, (3R,5R,6S)-

Base Information

Chemical Name:1-Oxa-7-azaspiro[4.5]decane-7-carboxylic acid, 6-phenyl-3-[2-(phenylmethoxy)-5-(trifluoromethoxy)phenyl]-, 1,1-dimethylethyl ester, (3R,5R,6S)-
CAS No.:200954-98-9
Molecular Formula:C33H36F3NO5
Molecular Weight:583.648
Hs Code.:

1-Oxa-7-azaspiro[4.5]decane-7-carboxylic acid,
6-phenyl-3-[2-(phenylmethoxy)-5-(trifluoromethoxy)phenyl]-,
1,1-dimethylethyl ester, (3R,5R,6S)-

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-Oxa-7-azaspiro[4.5]decane-7-carboxylic acid, 6-phenyl-3-[2-(phenylmethoxy)-5-(trifluoromethoxy)phenyl]-, 1,1-dimethylethyl ester, (3R,5R,6S)-

Chemical Property:

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Safty Information:

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MSDS Files:: SDS file from LookChem

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Technology Process of 1-Oxa-7-azaspiro[4.5]decane-7-carboxylic acid, 6-phenyl-3-[2-(phenylmethoxy)-5-(trifluoromethoxy)phenyl]-, 1,1-dimethylethyl ester, (3R,5R,6S)-

There total 11 articles about 1-Oxa-7-azaspiro[4.5]decane-7-carboxylic acid, 6-phenyl-3-[2-(phenylmethoxy)-5-(trifluoromethoxy)phenyl]-, 1,1-dimethylethyl ester, (3R,5R,6S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 200956-93-0
1-(benzyloxy)-2-iodo-4-(trifluoromethoxy)benzene

: 200956-77-0
(5R,6S)-6-phenyl-1-oxa-7-(tert-butoxycarbonyl)azaspiro[4.5]dec-3-ene

: (3S,5R,6S)-3-(2-benzyloxy-5-(trifluoromethoxy)phenyl)-6-phenyl-1-oxa-7-(tert-butoxycarbonyl)azaspiro[4.5]decane

: (2R,5R,6S)-2-(2-Benzyloxy-5-trifluoromethoxy-phenyl)-6-phenyl-1-oxa-7-aza-spiro[4.5]decane-7-carboxylic acid tert-butyl ester

: 200954-98-9
(3R,5S,6S)-3-(2-benzyloxy-5-(trifluoromethoxy)phenyl)-6-phenyl-1-oxa-7-(tert-butoxycarbonyl)azaspiro[4.5]decane

Guidance literature:: With palladium diacetate; tetrabutyl-ammonium chloride; potassium formate; lithium chloride; In N,N-dimethyl-formamide; at 60 ℃; for 37h;
DOI:10.1021/ol006944a

Reference yield:

: 200956-91-8
1-(benzyloxy)-4-(trifluoromethoxy)benzene

: 200954-98-9
(3R,5S,6S)-3-(2-benzyloxy-5-(trifluoromethoxy)phenyl)-6-phenyl-1-oxa-7-(tert-butoxycarbonyl)azaspiro[4.5]decane

Guidance literature:: Multi-step reaction with 2 steps

1: I₂; (CF₃COO)Ag / CHCl₃; CH₂Cl₂ / 18 h / 20 °C

2: 66 percent / Pd(OAc)2; KO₂CH; Bu₄NCl / LiCl / dimethylformamide / 37 h / 60 °C

With palladium diacetate; tetrabutyl-ammonium chloride; iodine; potassium formate; silver trifluoroacetate; lithium chloride; In dichloromethane; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/ol006944a

Reference yield:

: 200956-75-8
Z-(2S,3R)-1-tert-butoxycarbonyl-3-(3-hydroxyprop-1-en-1-yl)-2-phenylpiperidin-3-ol

: 200954-98-9
(3R,5S,6S)-3-(2-benzyloxy-5-(trifluoromethoxy)phenyl)-6-phenyl-1-oxa-7-(tert-butoxycarbonyl)azaspiro[4.5]decane

Guidance literature:: Multi-step reaction with 2 steps

1: 77 percent / Ph₃P; DEAD / tetrahydrofuran / 2 h / 0 - 20 °C

2: 66 percent / Pd(OAc)2; KO₂CH; Bu₄NCl / LiCl / dimethylformamide / 37 h / 60 °C

With palladium diacetate; tetrabutyl-ammonium chloride; potassium formate; triphenylphosphine; diethylazodicarboxylate; lithium chloride; In tetrahydrofuran; N,N-dimethyl-formamide; 1: Mitsunobu reaction;
DOI:10.1021/ol006944a