1,3,4-Oxadiazol-2(3H)-one, 3-[(5-chloro-2-methoxyphenyl)methyl]-5-[2-(1H-imidazol-1-yl)-4-(trifluoro methyl)phenyl]-

Base Information

• Chemical Name: 1,3,4-Oxadiazol-2(3H)-one, 3-[(5-chloro-2-methoxyphenyl)methyl]-5-[2-(1H-imidazol-1-yl)-4-(trifluoro methyl)phenyl]-
• CAS No.: 202822-74-0
• Molecular Formula: C20H14ClF3N4O3
• Molecular Weight: 450.804
• Mol file: 202822-74-0.mol

Synonyms:

Chemical Property of 1,3,4-Oxadiazol-2(3H)-one, 3-[(5-chloro-2-methoxyphenyl)methyl]-5-[2-(1H-imidazol-1-yl)-4-(trifluoro methyl)phenyl]-

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,3,4-Oxadiazol-2(3H)-one, 3-[(5-chloro-2-methoxyphenyl)methyl]-5-[2-(1H-imidazol-1-yl)-4-(trifluoro methyl)phenyl]-

There total 4 articles about 1,3,4-Oxadiazol-2(3H)-one, 3-[(5-chloro-2-methoxyphenyl)methyl]-5-[2-(1H-imidazol-1-yl)-4-(trifluoro methyl)phenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

1H-imidazole (288-32-4) + 3-[(5-chloro-2-methoxy-phenyl)methyl]-5-[2-fluoro-4-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2-(3H)-one (202822-72-8) → 3-[(5-chloro-2-methoxyphenyl)methyl]-5-[2-(1H-imidazol-1-yl)-4-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2-(3H)-one (202822-74-0)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 80 ℃; for 3h;

DOI:10.1021/jm061006n

Reference yield:

2-fluoro-4-(trifluoromethyl)benzoic acid hydrazide → 3-[(5-chloro-2-methoxyphenyl)methyl]-5-[2-(1H-imidazol-1-yl)-4-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2-(3H)-one (202822-74-0)

Guidance literature:

Multi-step reaction with 3 steps

1: Et₃N / tetrahydrofuran / 18 h / 24 °C

2: NaH / dimethylformamide / 18 h / 60 °C

3: 61 percent / NaH / dimethylformamide / 3 h / 80 °C

With sodium hydride; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/jm061006n

Reference yield:

5-(2-fluoro-4-trifluoromethyl-phenyl)-3H-[1,3,4]oxadiazol-2-one (220381-28-2) → 3-[(5-chloro-2-methoxyphenyl)methyl]-5-[2-(1H-imidazol-1-yl)-4-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2-(3H)-one (202822-74-0)

Guidance literature:

Multi-step reaction with 2 steps

1: NaH / dimethylformamide / 18 h / 60 °C

2: 61 percent / NaH / dimethylformamide / 3 h / 80 °C

With sodium hydride; In N,N-dimethyl-formamide;

DOI:10.1021/jm061006n

upstream raw materials:

1H-imidazole

3-[(5-chloro-2-methoxy-phenyl)methyl]-5-[2-fluoro-4-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2-(3H)-one

5-(2-fluoro-4-trifluoromethyl-phenyl)-3H-[1,3,4]oxadiazol-2-one

2-fluoro-4-(trifluoromethyl)benzoic acid