Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(4-azido-3-iodobenzoyl)-

Base Information

Chemical Name:Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(4-azido-3-iodobenzoyl)-
CAS No.:90990-97-9
Molecular Formula:C₂₁H₂₁IN₈O₃
Molecular Weight:560.354
Hs Code.:
DSSTox Substance ID:DTXSID90920021
Nikkaji Number:J1.828.992J
Wikidata:Q82892670
Mol file:90990-97-9.mol

Synonyms:(125I)iodoarylazidoprazosin;125I-IAAP;2-(4-(4-azido-3-iodobenzoyl)piperazin-1-yl)-4-amino-6,7-dimethoxyquinazoline;aryl azidoprazosin;azidoprazosin;CP 65,526;CP 65526;CP-65,526;iodoaryl azidoprazosin;iodoazidoaryl prazosin

Suppliers and Price of Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(4-azido-3-iodobenzoyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 3 raw suppliers

Chemical Property of Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(4-azido-3-iodobenzoyl)-

Chemical Property:

Boiling Point:°Cat760mmHg
Flash Point:°C
PSA：143.56000
Density:g/cm³
LogP:3.77486
XLogP3:4.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:5
Exact Mass:560.07813
Heavy Atom Count:33
Complexity:732

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4=CC(=C(C=C4)N=[N+]=[N-])I)N)OC

Technology Process of Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(4-azido-3-iodobenzoyl)-

There total 2 articles about Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(4-azido-3-iodobenzoyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 90990-96-8
2-[4-(4-amino-3-iodobenzoyl)piperazin-1-yl]-4-amino-6,7-dimethoxyquinazoline

: 90990-97-9
[125I]-Azidoprazosin

Guidance literature:: 2-[4-(4-amino-3-iodobenzoyl)piperazin-1-yl]-4-amino-6,7-dimethoxyquinazoline; With acetic acid; sodium nitrite; at 0 ℃; for 0.0833333h;

With sodium azide; for 0.0833333h; Further stages.;
DOI:10.1021/jo026217o

Reference yield:

: [4-(4-amino-6,7-dimethoxy-quinazolin-2-yl)-piperazin-1-yl]-(4-amino-phenyl)-methanone; dihydrochloride

: 90990-97-9
[125I]-Azidoprazosin

Guidance literature:: Multi-step reaction with 2 steps

1.1: 80 percent / benzyltrimethylammonium dichloroiodate; CaCO₃ / CH₂Cl₂; methanol / 16 h / 20 °C

2.1: aq. NaNO₂; AcOH / 0.08 h / 0 °C

2.2: 65 percent / aq. NaN₃ / 0.08 h

With N,N,N-trimethylbenzenemethanaminium dichloroiodate; acetic acid; calcium carbonate; sodium nitrite; In methanol; dichloromethane;
DOI:10.1021/jo026217o