2-Azetidinecarboxylic acid, 1-[(1S)-1-phenylethyl]-, methyl ester, (2S)-

Base Information

Chemical Name:2-Azetidinecarboxylic acid, 1-[(1S)-1-phenylethyl]-, methyl ester, (2S)-
CAS No.:204274-29-3
Molecular Formula:C13H17NO2
Molecular Weight:219.28000
Hs Code.:
DSSTox Substance ID:DTXSID00451311
Nikkaji Number:J1.641.735A
Wikidata:Q82271276
Mol file:204274-29-3.mol

Synonyms:204274-29-3;Methyl (2s)-1-[(1s)-1-phenylethyl]azetidine-2-carboxylate;2-Azetidinecarboxylic acid, 1-[(1S)-1-phenylethyl]-, methyl ester, (2S)-;SCHEMBL7064464;DTXSID00451311;FMYIXIBSKQXTLX-JQWIXIFHSA-N;PS-20964;E83510;(2S)-Methyl 1-(1-phenylethyl)azetidine-2-carboxylate;methyl N-[(S)-methylbenzyl]azetidine-2-(S)-carboxylate;(2S)-1-[(1S)-1-Phenylethyl]-2-azetidinecarboxylic acid methyl ester

Suppliers and Price of 2-Azetidinecarboxylic acid, 1-[(1S)-1-phenylethyl]-, methyl ester, (2S)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 2-Azetidinecarboxylic acid, 1-[(1S)-1-phenylethyl]-, methyl ester, (2S)-

Chemical Property:

PSA：29.54000
LogP:1.93280
XLogP3:2.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:219.125928785
Heavy Atom Count:16
Complexity:248

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C1=CC=CC=C1)N2CCC2C(=O)OC
Isomeric SMILES:C[C@@H](C1=CC=CC=C1)N2CC[C@H]2C(=O)OC

Technology Process of 2-Azetidinecarboxylic acid, 1-[(1S)-1-phenylethyl]-, methyl ester, (2S)-

There total 6 articles about 2-Azetidinecarboxylic acid, 1-[(1S)-1-phenylethyl]-, methyl ester, (2S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 29547-04-4,70288-65-2
methyl 2,4-dibromobutanoate

: 2627-86-3
(S)-1-phenyl-ethylamine

: 204274-30-6,186096-46-8
methyl (2R,1'S)-1-(1'-methyl)benzylazetidine-2-carboxylate

: 204274-29-3,186096-46-8
methyl (2S,1'S)-1-(1'-methyl)benzylazetidine-2-carboxylate

Guidance literature:: With sodium hydrogencarbonate; In acetonitrile; for 13h; Reflux;
DOI:10.1039/d1ra04585g

Reference yield:

: 204274-30-6,186096-46-8
methyl (2R,1'S)-1-(1'-methyl)benzylazetidine-2-carboxylate

: 204274-29-3,186096-46-8
methyl (2S,1'S)-1-(1'-methyl)benzylazetidine-2-carboxylate

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 ℃; for 2h;
DOI:10.1271/bbb.69.1892

Reference yield:

: 921600-20-6
dimethyl (1'S)-1-(1'-methyl)benzylazetidine-2,2-dicarboxylate

: 204274-30-6,186096-46-8
methyl (2R,1'S)-1-(1'-methyl)benzylazetidine-2-carboxylate

: 204274-29-3,186096-46-8
methyl (2S,1'S)-1-(1'-methyl)benzylazetidine-2-carboxylate

Guidance literature:: With 2,6-di-tert-butyl-4-methyl-phenol; 3 A molecular sieve; lithium chloride; In dimethyl sulfoxide; at 20 - 140 ℃; for 3h;
DOI:10.1271/bbb.69.1892