(2E)-2-cyano-3-(4-hydroxyphenyl)prop-2-enamide

Base Information

Chemical Name:(2E)-2-cyano-3-(4-hydroxyphenyl)prop-2-enamide
CAS No.:3695-89-4
Molecular Formula:C₁₀H₈N₂O₂
Molecular Weight:188.186
Hs Code.:
European Community (EC) Number:651-453-1
NSC Number:638074,117971
Nikkaji Number:J397.955E,J1.319.034H
Wikidata:Q76304053
ChEMBL ID:CHEMBL308048
Mol file:3695-89-4.mol

Synonyms:3695-89-4;(2E)-2-cyano-3-(4-hydroxyphenyl)prop-2-enamide;(E)-2-cyano-3-(4-hydroxyphenyl)prop-2-enamide;CHEMBL308048;ST 494;NSC117971;BDBM4355;SCHEMBL9539318;alpha-Cyano-4-hydroxycinnamamide;CCG-50900;NSC638074;alpha-Cyano-4-hydroxybenzeneacrylamide;AKOS016024289;NSC-117971;NSC-638074;benzylidenemalononitrile (BMN) deriv. 39;(2E)-2-cyano-3-(4-hydroxyphenyl)-2-propenamide;SR-01000640240-1

Suppliers and Price of (2E)-2-cyano-3-(4-hydroxyphenyl)prop-2-enamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of (2E)-2-cyano-3-(4-hydroxyphenyl)prop-2-enamide

Chemical Property:

Vapor Pressure:1.42E-09mmHg at 25°C
Boiling Point:473.1°Cat760mmHg
Flash Point:239.9°C
Density:1.35g/cm³
XLogP3:1.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:188.058577502
Heavy Atom Count:14
Complexity:293

Purity/Quality:: 95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC=C1C=C(C#N)C(=O)N)O
Isomeric SMILES:C1=CC(=CC=C1/C=C(\C#N)/C(=O)N)O

Technology Process of (2E)-2-cyano-3-(4-hydroxyphenyl)prop-2-enamide

There total 4 articles about (2E)-2-cyano-3-(4-hydroxyphenyl)prop-2-enamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 123-08-0,65581-83-1
4-hydroxy-benzaldehyde

: 107-91-5
cyanoacetic acid amide

: 122520-81-4,3695-89-4
ST 494

Guidance literature:: With triethylamine; at 20 ℃; for 24h;
DOI:10.1016/S0040-4020(03)00554-4

Reference yield: 75.0%

: 3785-90-8
2-(4-hydroxyphenylmethylene)malononitrile

: 122520-81-4,3695-89-4
ST 494

Guidance literature:: With manganese(IV) oxide; 4-chlorobenzaldoxime; In dichloromethane; at 20 ℃; for 4h; regiospecific reaction;

Reference yield: 64.0%

: 123-08-0,65581-83-1
4-hydroxy-benzaldehyde

: 109-77-3
malononitrile

: 122520-81-4,3695-89-4
ST 494

Guidance literature:: With trifluorormethanesulfonic acid; In 1,2-dichloro-ethane; at 110 ℃; for 24h; stereoselective reaction;
DOI:10.1039/c7nj05169g