{4-[(Methoxymethoxy)methyl]phenyl}methanol

Base Information

• Chemical Name: {4-[(Methoxymethoxy)methyl]phenyl}methanol
• CAS No.: 207223-84-5
• Molecular Formula: C10H14O3
• Molecular Weight: 182.219
• DSSTox Substance ID: DTXSID40578697
• Wikidata: Q82469001
• Mol file: 207223-84-5.mol

Synonyms:207223-84-5;{4-[(METHOXYMETHOXY)METHYL]PHENYL}METHANOL;DTXSID40578697

Chemical Property of {4-[(Methoxymethoxy)methyl]phenyl}methanol

Chemical Property:

• Boiling Point: 273.7±25.0 °C(Predicted)
• PSA: 38.69000
• Density: 1.102±0.06 g/cm3(Predicted)
• LogP: 1.29940
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 182.094294304
• Heavy Atom Count: 13
• Complexity: 119

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COCOCC1=CC=C(C=C1)CO

Technology Process of {4-[(Methoxymethoxy)methyl]phenyl}methanol

There total 9 articles about {4-[(Methoxymethoxy)methyl]phenyl}methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methyl 4-<(methoxymethoxy)methyl>benzoate (104292-95-7) → {4-[(methoxymethoxy)methyl]phenyl}methanol (207223-84-5)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 0.75h;

DOI:10.1021/jo0106086

Reference yield: 96.0%

C16H28O3Si → {4-[(methoxymethoxy)methyl]phenyl}methanol (207223-84-5)

Guidance literature:

With hafnium tetrakis(trifluoromethanesulfonate); In methanol; at 20 ℃; for 3h; chemoselective reaction;

DOI:10.1055/s-0037-1610307

Reference yield: 96.0%

Dimethoxymethane (109-87-5) + p-xylylene glycol (589-29-7) → {4-[(methoxymethoxy)methyl]phenyl}methanol (207223-84-5)

Guidance literature:

With 12-tungstophosphoric acid immobilized on [bmim][FeCl₄]; at 75 - 82 ℃; for 0.00972222h; Microwave irradiation;

DOI:10.1007/BF03249085

upstream raw materials:

p-xylylene glycol

chloromethyl methyl ether

methyl 4-<(methoxymethoxy)methyl>benzoate

1-chloro-4-[(methoxymethoxy)methyl]benzene

Downstream raw materials:

(4-(acetoxymethyl)phenyl)methanol