Boronic Acid, [1-(Triphenylmethyl)-1H-Pyrazol-4-YL

Base Information

• Chemical Name: Boronic Acid, [1-(Triphenylmethyl)-1H-Pyrazol-4-YL
• CAS No.: 207307-51-5
• Molecular Formula: C22H19BN2O2
• Molecular Weight: 354.216
• Mol file: 207307-51-5.mol

Synonyms:1-trityl-1H-4-pyrazolylboronic acid;1-trityl-1H-pyrazole-4-boronic acid;

Chemical Property of Boronic Acid, [1-(Triphenylmethyl)-1H-Pyrazol-4-YL

Chemical Property:

• Melting Point: 85-87 °C
• Boiling Point: 585.7±60.0 °C(Predicted)
• PKA: 7.46±0.10(Predicted)
• PSA: 58.28000
• Density: 1.13±0.1 g/cm3(Predicted)
• LogP: 2.40310
• Storage Temp.: 2-8°C

Purity/Quality:

98.5% ^*data from raw suppliers

(1-Trityl-1H-pyrazol-4-yl)boronicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Boronic Acid, [1-(Triphenylmethyl)-1H-Pyrazol-4-YL

There total 1 articles about Boronic Acid, [1-(Triphenylmethyl)-1H-Pyrazol-4-YL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

4-bromo-1-trityl-1H-pyrazole (95162-14-4) → (1-trityl-1H-pyrazol-4-yl)boronic acid (207307-51-5)

Guidance literature:

4-bromo-1-trityl-1H-pyrazole; With n-butyllithium; In diethyl ether; hexane; at -78 ℃; for 0.5h; Inert atmosphere;

With Trimethyl borate; In diethyl ether; hexane; Inert atmosphere;

With hydrogenchloride; water; In diethyl ether; hexane;

DOI:10.3987/COM-10-11954

Reference yield: 92.0%

(1-trityl-1H-pyrazol-4-yl)boronic acid (207307-51-5) + 1-Benzenesulfonyl-3-iodo-5-phenylsulfanyl-1H-pyrrolo[2,3-b]pyridine (923583-57-7) → 1-Benzenesulfonyl-5-phenylsulfanyl-3-(1-trityl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine (923583-58-8)

Guidance literature:

With sodium carbonate; lithium chloride; bis-triphenylphosphine-palladium(II) chloride; In ethanol; water; toluene; for 0.5h; Heating / reflux;

Reference yield: 81.0%

1-benzenesulfonyl-3-iodo-5-morpholin-4-yl-1H-pyrrolo[2,3-b]pyridine + (1-trityl-1H-pyrazol-4-yl)boronic acid (207307-51-5) → 1-benzenesulfonyl-5-morpholin-4-yl-3-(trityl-1H-pyrazol-4-yl)-pyrrolo[2,3-B]pyridine (757978-28-2)

Guidance literature:

With sodium carbonate; lithium chloride; bis-triphenylphosphine-palladium(II) chloride; In ethanol; water; toluene; at 105 ℃; for 2h;

upstream raw materials:

4-bromo-1-trityl-1H-pyrazole

Downstream raw materials:

6-(1-trityl-1H-4-pyrazolyl)imidazo[1,2-a]pyridine

1-benzenesulfonyl-5-morpholin-4-yl-3-(trityl-1H-pyrazol-4-yl)-pyrrolo[2,3-B]pyridine

1-Benzenesulfonyl-5-bromo-3-(1-trityl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine

6,6-Dimethyl-3-methylthio-1-((1-triphenylmethyl)pyrazol-4-yl)-4,5,6,7-tetrahydrobenzo[c]thiophen-4-one