Benzyl 5-fluorospiro[indoline-3,4'-piperidine]-1'-carboxylate

Base Information

Chemical Name:Benzyl 5-fluorospiro[indoline-3,4'-piperidine]-1'-carboxylate
CAS No.:209348-85-6
Molecular Formula:C20H21FN2O2
Molecular Weight:340.397
Hs Code.:2933990090
DSSTox Substance ID:DTXSID60598418
Wikidata:Q82494174
Mol file:209348-85-6.mol

Synonyms:209348-85-6;BENZYL 5-FLUOROSPIRO[INDOLINE-3,4'-PIPERIDINE]-1'-CARBOXYLATE;benzyl 5-fluorospiro[1,2-dihydroindole-3,4'-piperidine]-1'-carboxylate;SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID, 5-FLUORO-1,2-DIHYDRO-, PHENYLMETHYL ESTER;BENZYL 5-FLUORO-1,2-DIHYDROSPIRO[INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLATE;C20H21FN2O2;SCHEMBL4979362;SCHEMBL4979370;DTXSID60598418;Benzyl5-fluorospiro[indoline-3,4'-piperidine]-1'-carboxylate;MFCD12198574;AKOS016005661;MB11749;AM803500;AS-74558;DB-014708;CS-0035681;F17544;1''-Cbz-5-fluorospiro[1,2-dihydroindole-3,4''-piperidine];Benzyl 5-fluoro-1,2-dihydro-1'H-spiro[indole-3,4'-piperidine]-1'-carboxylate

Suppliers and Price of Benzyl 5-fluorospiro[indoline-3,4'-piperidine]-1'-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
Benzyl5-fluorospiro[indoline-3,4'-piperidine]-1'-carboxylate 95+%
1g
$ 510.00

Chemenu
Benzyl5-fluorospiro[indoline-3,4''-piperidine]-1''-carboxylate 95%
1g
$ 482.00

American Custom Chemicals Corporation
BENZYL 5-FLUOROSPIRO(INDOLINE-3,4'-PIPERIDINE)-1'-CARBOXYLATE 95.00%
5G
$ 3811.50

Alichem
Benzyl5-fluorospiro[indoline-3,4'-piperidine]-1'-carboxylate
1g
$ 420.16

AK Scientific
Benzyl5-fluorospiro[indoline-3,4'-piperidine]-1'-carboxylate
250mg
$ 714.00

Total 12 raw suppliers

Chemical Property of Benzyl 5-fluorospiro[indoline-3,4'-piperidine]-1'-carboxylate

Chemical Property:

Boiling Point:503.2oC at 760 mmHg
Flash Point:258.1oC
PSA：41.57000
LogP:3.99750
XLogP3:3.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:340.15870608
Heavy Atom Count:25
Complexity:472

Purity/Quality:

99% ^*data from raw suppliers

Benzyl5-fluorospiro[indoline-3,4'-piperidine]-1'-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN(CCC12CNC3=C2C=C(C=C3)F)C(=O)OCC4=CC=CC=C4

Technology Process of Benzyl 5-fluorospiro[indoline-3,4'-piperidine]-1'-carboxylate

There total 3 articles about Benzyl 5-fluorospiro[indoline-3,4'-piperidine]-1'-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 823-85-8
4-fluorophenyhydrazine hydrochloride

: 138163-08-3
N-(benzyloxycarbonyl)piperidine-4-carboxaldehyde

: 209348-85-6
benzyl 5-fluoro-1,2-dihydro-1'H-spiro[indole-3,4'-piperidin]-1'-carboxylate

Guidance literature:: 4-fluorophenyhydrazine hydrochloride; N-(benzyloxycarbonyl)piperidine-4-carboxaldehyde; With trifluoroacetic acid; In toluene; acetonitrile; at 20 - 50 ℃; for 23h;

With sodium tetrahydroborate; In methanol; toluene; acetonitrile; at 0 - 20 ℃; for 3h;

Reference yield:

: 138163-08-3
N-(benzyloxycarbonyl)piperidine-4-carboxaldehyde

: 371-14-2
4-fluorophenylhydrazine

: 209348-85-6
benzyl 5-fluoro-1,2-dihydro-1'H-spiro[indole-3,4'-piperidin]-1'-carboxylate

Guidance literature:: N-(benzyloxycarbonyl)piperidine-4-carboxaldehyde; 4-fluorophenylhydrazine; With trifluoroacetic acid; In toluene; acetonitrile;

With sodium tetrahydroborate; In methanol;
DOI:10.1016/j.bmcl.2008.04.034