5-chloro-1H-indole-2-carboxamide

Base Information

Chemical Name:5-chloro-1H-indole-2-carboxamide
CAS No.:21109-01-3
Molecular Formula:C9H7ClN2O
Molecular Weight:194.62
Hs Code.:
DSSTox Substance ID:DTXSID00406442
Nikkaji Number:J2.858.161K
Mol file:21109-01-3.mol

Synonyms:5-chloro-1H-indole-2-carboxamide;21109-01-3;1H-Indole-2-carboxamide, 5-chloro-;MFCD07364576;5-chloroindole-2-amide;SCHEMBL764543;DTXSID00406442;AMY24657;WAA10901;AKOS004116766;BS-16484;SY251599;CS-0131086;C74007;Z300502560

Suppliers and Price of 5-chloro-1H-indole-2-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 6 raw suppliers

Chemical Property of 5-chloro-1H-indole-2-carboxamide

Chemical Property:

XLogP3:1.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:1
Exact Mass:194.0246905
Heavy Atom Count:13
Complexity:222

Purity/Quality:: NLT 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC2=C(C=C1Cl)C=C(N2)C(=O)N

Technology Process of 5-chloro-1H-indole-2-carboxamide

There total 4 articles about 5-chloro-1H-indole-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 4792-67-0
5-chloro-indole-2-carboxylic acid ethyl ester

: 21109-01-3
5-chloro-1H-indole-2-carboxamide

Guidance literature:: With ammonia; calcium chloride; In methanol; at 80 ℃; for 24h; under 1275.13 Torr; Inert atmosphere;
DOI:10.1016/j.tetlet.2010.05.075

Reference yield:

: 10517-21-2
5-chloro-1H-Indole-2-carboxylic acid

: 21109-01-3
5-chloro-1H-indole-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: SOCl₂ / CHCl₃ / 2 h / Heating

2: aq. NH₃

With ammonium hydroxide; thionyl chloride; In chloroform;
DOI:10.1016/j.bmcl.2005.08.110