3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2-chloro-6-methyl-4-(3-nitrophenyl)-, 3-methyl-5-(1-methylethyl) ester

Base Information

Chemical Name:3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2-chloro-6-methyl-4-(3-nitrophenyl)-, 3-methyl-5-(1-methylethyl) ester
CAS No.:107610-52-6
Molecular Formula:C₁₈H₁₉ClN₂O₆
Molecular Weight:394.812
Hs Code.:
DSSTox Substance ID:DTXSID20910379

Synonyms:SUN 5141;107610-52-6;3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2-chloro-6-methyl-4-(3-nitrophenyl)-, 3-methyl-5-(1-methylethyl) ester;DTXSID20910379;LS-131195;3-Methyl 5-propan-2-yl 2-chloro-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Suppliers and Price of 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2-chloro-6-methyl-4-(3-nitrophenyl)-, 3-methyl-5-(1-methylethyl) ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2-chloro-6-methyl-4-(3-nitrophenyl)-, 3-methyl-5-(1-methylethyl) ester

Chemical Property:

Vapor Pressure:1.85E-10mmHg at 25°C
Boiling Point:508.5°Cat760mmHg
Flash Point:261.3°C
Density:1.35g/cm³
XLogP3:3.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:6
Exact Mass:394.0931640
Heavy Atom Count:27
Complexity:695

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(C(C(=C(N1)Cl)C(=O)OC)C2=CC(=CC=C2)[N+](=O)[O-])C(=O)OC(C)C

Technology Process of 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2-chloro-6-methyl-4-(3-nitrophenyl)-, 3-methyl-5-(1-methylethyl) ester

There total 4 articles about 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2-chloro-6-methyl-4-(3-nitrophenyl)-, 3-methyl-5-(1-methylethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.0%

: 107610-34-4
2-hydroxy-5-isopropoxycarbonyl-3-methoxycarbonyl-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine

: 107610-52-6
2-Chloro-6-methyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 5-isopropyl ester 3-methyl ester

Guidance literature:: With trichlorophosphate; for 3h; Heating;
DOI:10.1248/cpb.37.2117

Reference yield:

: 542-08-5
isopropyl acetoacetate

: 107610-52-6
2-Chloro-6-methyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 5-isopropyl ester 3-methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 28percent NH₄OH, / methanol; H₂O / 16 h / Heating

2: methanol / 4.5 h / Heating

3: 88 percent / Et₃N, / methanol / 16 h / Heating

4: 11 percent / POCl₃, / 3 h / Heating

With ammonium hydroxide; triethylamine; trichlorophosphate; In methanol; water;
DOI:10.1248/cpb.37.2117

Reference yield:

: 14205-46-0
isopropyl 3-aminocrotonate

: 107610-52-6
2-Chloro-6-methyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 5-isopropyl ester 3-methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: methanol / 4.5 h / Heating

2: 88 percent / Et₃N, / methanol / 16 h / Heating

3: 11 percent / POCl₃, / 3 h / Heating

With triethylamine; trichlorophosphate; In methanol;
DOI:10.1248/cpb.37.2117