4H-Pyrazolo[3,4-d]pyrimidin-4-one, 2,5-dihydro-2-methyl- (9CI)

Base Information

• Chemical Name: 4H-Pyrazolo[3,4-d]pyrimidin-4-one, 2,5-dihydro-2-methyl- (9CI)
• CAS No.: 21230-41-1
• Molecular Formula: C6H6N4O
• Molecular Weight: 150.13800
• Hs Code.: 2933990090
• Mol file: 21230-41-1.mol

Synonyms:4h-pyrazolo[3,4-d]pyrimidin-4-one,2,5-dihydro-2-methyl;

Chemical Property of 4H-Pyrazolo[3,4-d]pyrimidin-4-one, 2,5-dihydro-2-methyl- (9CI)

Chemical Property:

• PSA: 63.83000
• LogP: 0.06890

Purity/Quality:

97% ^*data from raw suppliers

2-Methyl-1H-pyrazolo[3,4-d]pyrimidin-4(2H)-one 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4H-Pyrazolo[3,4-d]pyrimidin-4-one, 2,5-dihydro-2-methyl- (9CI)

There total 4 articles about 4H-Pyrazolo[3,4-d]pyrimidin-4-one, 2,5-dihydro-2-methyl- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

4-methoxy-2-methyl-1H-pyrazolo-<3,4-d>pyrimidine (96096-14-9) → 2-Methyl-allopurinol (21230-41-1)

Guidance literature:

With sodium hydroxide; In methanol; for 16h; Ambient temperature;

DOI:10.1021/jo00211a012

Reference yield:

4-methoxy-1H-pyrazolo[3,4-d]-pyrimidine (5399-93-9) → 2-Methyl-allopurinol (21230-41-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 24 percent / tetrabuthylammonium hydrogen sulphate, NaOH / benzene; H₂O / 0.5 h / Ambient temperature

2: 87 percent / 1 N NaOH / methanol / 16 h / Ambient temperature

With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; In methanol; water; benzene;

DOI:10.1021/jo00211a012

Reference yield:

3-amino-1-methyl-1H-pyrazole-4-carboxylic acid ethyl ester (21230-43-3) + formamide (77287-34-4,77287-35-5,60100-09-6) → 2-Methyl-allopurinol (21230-41-1)

Guidance literature:

DOI:10.1002/hlca.19590420318

upstream raw materials:

3-amino-1-methyl-1H-pyrazole-4-carboxylic acid ethyl ester

formamide

4-methoxy-2-methyl-1H-pyrazolo-<3,4-d>pyrimidine

4-methoxy-1H-pyrazolo[3,4-d]-pyrimidine