1H-Pyrazolo[3,4-c]pyridazin-3(2H)-one

Base Information

• Chemical Name: 1H-Pyrazolo[3,4-c]pyridazin-3(2H)-one
• CAS No.: 2125-85-1
• Molecular Formula: C5H4N4O
• Molecular Weight: 136.11100
• Hs Code.: 2933990090
• Mol file: 2125-85-1.mol

Synonyms:3-hydroxypyrazolo<3,4-c>3-Hydroxy-1H-pyrazolo

Chemical Property of 1H-Pyrazolo[3,4-c]pyridazin-3(2H)-one

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 459.827oC at 760 mmHg
• Flash Point: 231.895oC
• PSA: 74.69000
• Density: 1.702g/cm3
• LogP: 0.05850

Purity/Quality:

95% ^*data from raw suppliers

1H-Pyrazolo[3,4-c]pyridazin-3(2H)-one 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Pyrazolo[3,4-c]pyridazin-3(2H)-one

There total 3 articles about 1H-Pyrazolo[3,4-c]pyridazin-3(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

Methyl 2-aminothiophene-3-carboxylate (4651-81-4) → 3-hydroxypyrazolo<3,4-c>pyridazine (2125-85-1)

Guidance literature:

With hydrazine hydrate; In methanol; for 37h; Heating;

DOI:10.1021/jo00029a046

Reference yield:

→ 1,2-dihydro-pyrazolo[3,4-c]pyridazin-3-one (2125-85-1)

Guidance literature:

/BRN= 608519/, 80percentig.Hydrazinhydrat, Wasserbad;

Reference yield:

→ 3-hydroxypyrazolo<3,4-c>pyridazine (2125-85-1)

Guidance literature:

/BRN= 608519/, 80ig.Hydrazinhydrat, Wasserbad;

upstream raw materials:

Methyl 2-aminothiophene-3-carboxylate

Refernces

• 1、 Reinecke, Manfred G.,Woodrow, Thomas A.,Brown, E. Sherwood. "Pyrazolopyridazines from Hydrazine and Aminothiophenecarboxylates". . p. 1018 - 1021. Retrieved 2007/10/02.