2-Methylbenzo[f]chromen-3-one

Base Information

Chemical Name:2-Methylbenzo[f]chromen-3-one
CAS No.:21315-44-6
Molecular Formula:C14H10O2
Molecular Weight:210.232
Hs Code.:
ChEMBL ID:CHEMBL447225
DSSTox Substance ID:DTXSID10481583
Nikkaji Number:J523.944C
Wikidata:Q82317069
Mol file:21315-44-6.mol

Synonyms:2-Methylbenzo[f]chromen-3-one;21315-44-6;CHEMBL447225;2-METHYL-3H-BENZO[F]CHROMEN-3-ONE;SCHEMBL12304240;DTXSID10481583;BDBM50278259;SY308553

Suppliers and Price of 2-Methylbenzo[f]chromen-3-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Methylbenzo[f]chromen-3-one

Chemical Property:

XLogP3:3.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:0
Exact Mass:210.068079557
Heavy Atom Count:16
Complexity:332

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC2=C(C=CC3=CC=CC=C32)OC1=O

Technology Process of 2-Methylbenzo[f]chromen-3-one

There total 3 articles about 2-Methylbenzo[f]chromen-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 197314-89-9
(E)-3-(2-hydroxynaphthalen-1-yl)-2-methyl-acrylic acid ethyl ester

: 21315-44-6
3-Methyl-2(H)-oxo-naphtho<2,1-b>pyran

: 1630951-91-5
N-4-methoxybenzyl (E)-3-(2-hydroxynaphthalen-1-yl)-2-methylpropenamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: ethanol; water / 2 h / Alkaline conditions; Reflux

1.2: 20 °C / pH 2

2.1: 1-hydroxy-pyrrolidine-2,5-dione; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 3 h / 20 °C

2.2: 12 h / 20 °C

With 1-hydroxy-pyrrolidine-2,5-dione; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.3987/COM-14-12990

Reference yield:

: 708-06-5
2-hydroxynaphthalene-1-carbaldehyde

: 21315-44-6
3-Methyl-2(H)-oxo-naphtho<2,1-b>pyran

: 1630951-91-5
N-4-methoxybenzyl (E)-3-(2-hydroxynaphthalen-1-yl)-2-methylpropenamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: toluene / 0.5 h / 20 °C / Inert atmosphere

2.1: ethanol; water / 2 h / Alkaline conditions; Reflux

2.2: 20 °C / pH 2

3.1: 1-hydroxy-pyrrolidine-2,5-dione; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 3 h / 20 °C

3.2: 12 h / 20 °C

With 1-hydroxy-pyrrolidine-2,5-dione; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; water; N,N-dimethyl-formamide; toluene;
DOI:10.3987/COM-14-12990

Reference yield:

: 1630951-91-5
N-4-methoxybenzyl (E)-3-(2-hydroxynaphthalen-1-yl)-2-methylpropenamide

: 76-05-1
trifluoroacetic acid

: 946132-51-0
4-methoxybenzylamine trifluoroacetate salt

: 21315-44-6
3-Methyl-2(H)-oxo-naphtho<2,1-b>pyran

Guidance literature:: N-4-methoxybenzyl (E)-3-(2-hydroxynaphthalen-1-yl)-2-methylpropenamide; In methanol; at 20 ℃; for 6h; Irradiation; Inert atmosphere;

trifluoroacetic acid; In methanol; Inert atmosphere;
DOI:10.3987/COM-14-12990