Technology Process of Octanoic acid, 7-hydroxy-3-(phenylmethoxy)-, (3S,7R)-
There total 11 articles about Octanoic acid, 7-hydroxy-3-(phenylmethoxy)-, (3S,7R)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
2,3-dicyano-5,6-dichloro-p-benzoquinone;
In
dichloromethane;
at 25 ℃;
for 3h;
stereoselective reaction;
DOI:10.1007/s00706-015-1526-4
- Guidance literature:
-
With
potassium hydroxide;
In
methanol; water;
Ambient temperature;
DOI:10.1246/cl.1998.831
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 95 percent / hydrogen / palladium on activated carbon / ethanol / 10 h / 20 °C
2: 90 percent / DIBAL / toluene / 2 h / -78 °C
3: 89 percent / tin(II) trifluoromethanesulfonate; tributyltin fluoride; chiral diamine deriv. of D-proline / CH2Cl2 / 3 h / -78 °C
4: 93 percent / N,N-diisopropylethylamine; silver trifluoroacetate / methanol / 10 h / 20 °C
5: trifluoromethanesulfonic acid / CH2Cl2 / 0.5 h / 20 °C
6: aq. potassium hydroxide / methanol / 3 h / 20 °C
With
potassium hydroxide; tin(II) trifluoromethanesulfonate; trifluorormethanesulfonic acid; chiral diamine deriv. of D-proline; hydrogen; silver trifluoroacetate; diisobutylaluminium hydride; tributyltin fluoride; N-ethyl-N,N-diisopropylamine;
palladium on activated charcoal;
In
methanol; ethanol; dichloromethane; toluene;
1: Catalytic hydrogenation / 2: Reduction / 3: aldol reaction / 4: transesterification / 5: Etherification / 6: Hydrolysis;
DOI:10.3987/COM-99-S85
