8-(3-Fluorophenyl)-1,4-dioxaspiro[4.5]decane

Base Information

Chemical Name:8-(3-Fluorophenyl)-1,4-dioxaspiro[4.5]decane
CAS No.:217476-14-7
Molecular Formula:C14H17FO2
Molecular Weight:236.286
Hs Code.:
DSSTox Substance ID:DTXSID60596272
Nikkaji Number:J2.054.932G
Wikidata:Q82491491
Mol file:217476-14-7.mol

Synonyms:8-(3-fluorophenyl)-1,4-dioxaspiro[4.5]decane;217476-14-7;SCHEMBL731682;DTXSID60596272;VRUQHQZGKWOAPF-UHFFFAOYSA-N;8-(3-fluorophenyl)-1,4-dioxaspiro[4,5]decane

Suppliers and Price of 8-(3-Fluorophenyl)-1,4-dioxaspiro[4.5]decane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 8-(3-Fluorophenyl)-1,4-dioxaspiro[4.5]decane

Chemical Property:

XLogP3:2.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:236.12125794
Heavy Atom Count:17
Complexity:253

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC2(CCC1C3=CC(=CC=C3)F)OCCO2

Technology Process of 8-(3-Fluorophenyl)-1,4-dioxaspiro[4.5]decane

There total 6 articles about 8-(3-Fluorophenyl)-1,4-dioxaspiro[4.5]decane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.1%

: 8-(3-fluorophenyl)-1,4-dioxaspiro[4,5]dec-7-ene

: 217476-14-7
8-(3-fluorophenyl)-1,4-dioxaspiro[4.5]decane

Guidance literature:: With hydrogen; 1% Pd/C; In toluene; at 20 ℃;

Reference yield:

: 1073-06-9
3-fluorobromobenzene

: 217476-14-7
8-(3-fluorophenyl)-1,4-dioxaspiro[4.5]decane

Guidance literature:: Multi-step reaction with 3 steps

1.1: magnesium / tetrahydrofuran / Reflux

1.2: 20 °C / Reflux

2.1: pyridine; 1,8-diazabicyclo[5.4.0]undec-7-ene; trichlorophosphate / 0 - 80 °C

3.1: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 5 h / 30003 Torr

With pyridine; palladium 10% on activated carbon; hydrogen; magnesium; 1,8-diazabicyclo[5.4.0]undec-7-ene; trichlorophosphate; In tetrahydrofuran; methanol; ethyl acetate;
DOI:10.1021/ja309262f

Reference yield:

: 8-(3-fluorophenyl)-1,4-dioxaspiro[4.5]decan-8-ol

: 217476-14-7
8-(3-fluorophenyl)-1,4-dioxaspiro[4.5]decane

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine; 1,8-diazabicyclo[5.4.0]undec-7-ene; trichlorophosphate / 0 - 80 °C

2: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 5 h / 30003 Torr

With pyridine; palladium 10% on activated carbon; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; trichlorophosphate; In methanol; ethyl acetate;
DOI:10.1021/ja309262f