3-Thiazolidinecarboxylic acid, 4-[[[(1R)-1-[[(cyclohexylmethyl)thio]methyl]-2-[[(4-methoxyphenyl)methyl] amino]-2-oxoethyl]amino]carbonyl]-, 1,1-dimethylethyl ester, (4R)-

Base Information

Chemical Name:3-Thiazolidinecarboxylic acid, 4-[[[(1R)-1-[[(cyclohexylmethyl)thio]methyl]-2-[[(4-methoxyphenyl)methyl] amino]-2-oxoethyl]amino]carbonyl]-, 1,1-dimethylethyl ester, (4R)-
CAS No.:219625-66-8
Molecular Formula:C₂₇H₄₁N₃O₅S₂
Molecular Weight:551.772
Hs Code.:

3-Thiazolidinecarboxylic acid,
4-[[[(1R)-1-[[(cyclohexylmethyl)thio]methyl]-2-[[(4-methoxyphenyl)methyl]
amino]-2-oxoethyl]amino]carbonyl]-, 1,1-dimethylethyl ester, (4R)-

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Chemical Property of 3-Thiazolidinecarboxylic acid, 4-[[[(1R)-1-[[(cyclohexylmethyl)thio]methyl]-2-[[(4-methoxyphenyl)methyl] amino]-2-oxoethyl]amino]carbonyl]-, 1,1-dimethylethyl ester, (4R)-

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Technology Process of 3-Thiazolidinecarboxylic acid, 4-[[[(1R)-1-[[(cyclohexylmethyl)thio]methyl]-2-[[(4-methoxyphenyl)methyl] amino]-2-oxoethyl]amino]carbonyl]-, 1,1-dimethylethyl ester, (4R)-

There total 7 articles about 3-Thiazolidinecarboxylic acid, 4-[[[(1R)-1-[[(cyclohexylmethyl)thio]methyl]-2-[[(4-methoxyphenyl)methyl] amino]-2-oxoethyl]amino]carbonyl]-, 1,1-dimethylethyl ester, (4R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2550-36-9
Cyclohexylmethyl bromide

: 219625-66-8
(2R)-N-(4-methoxybenzyl)-3-cyclohexylmethylthio-2-((4R)-3-t-butoxycarbonyl-thiazolidin-4-ylcarbonylamino)propanamide

Guidance literature:: Multi-step reaction with 5 steps

1: NaOH; Bu₄NI / ethanol; H₂O / 72 h

2: 621 g / NaOH; Bu₄NI / ethanol / 1 h

3: 81 percent / HOBt; EDC / dimethylformamide / 2 h

4: 419 g / HCl / dioxane / 1 h / 20 °C

5: N-methylmorpholine; HOBt; EDC / dimethylformamide / 1.5 h

With 4-methyl-morpholine; hydrogenchloride; sodium hydroxide; tetra-(n-butyl)ammonium iodide; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(02)00558-8

Reference yield:

: 219626-94-5
(2R)-2-(t-butoxycarbonylamino)-3-cyclohexylmethylthiopropanoic acid

: 219625-66-8
(2R)-N-(4-methoxybenzyl)-3-cyclohexylmethylthio-2-((4R)-3-t-butoxycarbonyl-thiazolidin-4-ylcarbonylamino)propanamide

Guidance literature:: Multi-step reaction with 3 steps

1: 81 percent / HOBt; EDC / dimethylformamide / 2 h

2: 419 g / HCl / dioxane / 1 h / 20 °C

3: N-methylmorpholine; HOBt; EDC / dimethylformamide / 1.5 h

With 4-methyl-morpholine; hydrogenchloride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(02)00558-8

Reference yield:

: 473421-00-0
(R)-2-Amino-3-cyclohexylmethylsulfanyl-propionic acid

: 219625-66-8
(2R)-N-(4-methoxybenzyl)-3-cyclohexylmethylthio-2-((4R)-3-t-butoxycarbonyl-thiazolidin-4-ylcarbonylamino)propanamide

Guidance literature:: Multi-step reaction with 4 steps

1: 621 g / NaOH; Bu₄NI / ethanol / 1 h

2: 81 percent / HOBt; EDC / dimethylformamide / 2 h

3: 419 g / HCl / dioxane / 1 h / 20 °C

4: N-methylmorpholine; HOBt; EDC / dimethylformamide / 1.5 h

With 4-methyl-morpholine; hydrogenchloride; sodium hydroxide; tetra-(n-butyl)ammonium iodide; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In 1,4-dioxane; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(02)00558-8