naltiazem

Base Information

• Chemical Name: naltiazem
• CAS No.: 108383-95-5
• Molecular Formula: C₂₆H₂₈N₂O₄S
• Molecular Weight: 464.585
• Mol file: 108383-95-5.mol

Synonyms:Naphtho[1,2-b][1,4]thiazepin-4(5H)-one,3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-,(2S-cis)-; (+)-Ro 23-6152; Naltiazem

Chemical Property of naltiazem

Chemical Property:

• Vapor Pressure: 1.71E-17mmHg at 25°C
• Boiling Point: 663.9°C at 760 mmHg
• Flash Point: 355.3°C
• PSA: 84.38000
• Density: 1.28g/cm³
• LogP: 4.58670

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of naltiazem

There total 3 articles about naltiazem which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

→ cis-(+)-3-(acetyloxy)-2,3-dihydro-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)naphtho[1,2-b][1,4]thiazepin-4(5H)-one (108383-95-5)

Guidance literature:

Reference yield:

(+)-cis-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-naphtho<1,2-b><1,4>thiazepin-4(5H)-one hydrochloride (108383-88-6) → cis-(+)-3-(acetyloxy)-2,3-dihydro-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)naphtho[1,2-b][1,4]thiazepin-4(5H)-one (108383-95-5)

Guidance literature:

With acetic anhydride; In ethyl acetate;

Reference yield:

(+/-)-trans-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-5-[2-(dimethylamino)ethyl]naphtho[1,2-b]-1,4-thiazepin-4(5H)-one hydrochloride → (+/-)-trans-3-(acetyloxy)-2,3-dihydro-2-(4-methoxyphenyl)-5-[2-(dimethylamino)ethyl]naphtho[1,2-b]-1,4-thiazepin-4(5H)-one (108383-95-5)

Guidance literature:

With acetic anhydride; In ethyl acetate;

upstream raw materials:

(+)-cis-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-naphtho<1,2-b><1,4>thiazepin-4(5H)-one hydrochloride