2-PYRROLIDIN-2-YLPYRIDINE

Base Information

• Chemical Name: 2-PYRROLIDIN-2-YLPYRIDINE
• CAS No.: 22083-78-9
• Molecular Formula: C9H12N2
• Molecular Weight: 148.20500
• Hs Code.: 2933990090
• Mol file: 22083-78-9.mol

Synonyms:(S)-2-(2-Pyrrolidinyl)-pyridine;2-PYRROLIDIN-2-YLPYRIDINE;2-(PYRROLIDIN-2-YL)PYRIDINE;2-PYRROLIDIN-2-YL-PYRIDINE;

Chemical Property of 2-PYRROLIDIN-2-YLPYRIDINE

Chemical Property:

• Boiling Point: 60 °C(Press: 0.4 Torr)
• PKA: 8.47±0.10(Predicted)
• PSA: 24.92000
• Density: 1.042±0.06 g/cm3(Predicted)
• LogP: 1.83490
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%min ^*data from raw suppliers

(S)-2-(2-Pyrrolidinyl)-pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (S)-2-(2-Pyrrolidinyl)-pyridine is used as a catalyst in the enantioselective addition of diethylzinc to aldehydes to form optically active secondary alcohols in high yields.

Technology Process of 2-PYRROLIDIN-2-YLPYRIDINE

There total 6 articles about 2-PYRROLIDIN-2-YLPYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-<(2S)-1-benzyloxycarbonyl-2-pyrrolidinyl>pyridine (133031-58-0) → 2-<(2S)-2-pyrrolidinyl>pyridine (22083-78-9)

Guidance literature:

With hydrogenchloride; for 1h; Heating;

DOI:10.1055/s-1990-27109

Reference yield: 50.0%

2-((S)-1-((R)-1-(4-methoxyphenyl)ethyl)pyrrolidin-2-yl)pyridine → 2-<(2S)-2-pyrrolidinyl>pyridine (22083-78-9)

Guidance literature:

With trifluoroacetic acid; at 50 ℃; for 12h;

Reference yield:

(2S)-2-cyanopyrrolidine-1-carboxylic acid benzyl ester (63808-36-6) → 2-<(2S)-2-pyrrolidinyl>pyridine (22083-78-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / (π-cyclopentadienyl)cobalt-1,5-cyclooctadiene / toluene / 22 h / 110 °C / 10500.8 Torr

2: 92 percent / 6N HCl / 1 h / Heating

With hydrogenchloride; (η5-cyclopentadienyl)-η4-cycloocta-1,5-dienecobalt(I); In toluene;

DOI:10.1055/s-1990-27109

upstream raw materials:

2-<(2S)-1-benzyloxycarbonyl-2-pyrrolidinyl>pyridine

(2S)-2-cyanopyrrolidine-1-carboxylic acid benzyl ester

2-pyridine-γ-oxo butanal

2-Cyanopyridine

Downstream raw materials:

2-<(2S)-1-benzyl-2-pyrrolidinyl>pyridine

2-<1-(α-methoxy-α-trifluoromethylphenylacetyl)-2-pyrrolidinyl>pyridine

2-nicotine