3-Ethoxy-4-phenylcyclobut-3-ene-1,2-dione

Base Information

• Chemical Name: 3-Ethoxy-4-phenylcyclobut-3-ene-1,2-dione
• CAS No.: 22118-95-2
• Molecular Formula: C12H10O3
• Molecular Weight: 202.21
• DSSTox Substance ID: DTXSID00511782
• Nikkaji Number: J660.674A
• Wikidata: Q82370750
• Mol file: 22118-95-2.mol

Synonyms:3-Ethoxy-4-phenylcyclobut-3-ene-1,2-dione;22118-95-2;SCHEMBL9760352;DTXSID00511782

Chemical Property of 3-Ethoxy-4-phenylcyclobut-3-ene-1,2-dione

Chemical Property:

• XLogP3: 1.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 202.062994177
• Heavy Atom Count: 15
• Complexity: 322

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC1=C(C(=O)C1=O)C2=CC=CC=C2

Technology Process of 3-Ethoxy-4-phenylcyclobut-3-ene-1,2-dione

There total 4 articles about 3-Ethoxy-4-phenylcyclobut-3-ene-1,2-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

N-(2,2,4-triethoxy-3-phenyl-2-cyclobutylidene)isopropylamine → 3-ethoxy-4-phenyl-3-cyclobutylene-1,2-dione (22118-95-2)

Guidance literature:

With hydrogenchloride; In dichloromethane; for 2h; Heating;

DOI:10.1021/jo0502044

Reference yield: 52.0%

phenyllithium (591-51-5) + 3,4-diethoxy-3-cyclobuten-1,2-dione (5231-87-8) → 3-ethoxy-4-phenyl-3-cyclobutylene-1,2-dione (22118-95-2)

Guidance literature:

phenyllithium; 3,4-diethoxy-3-cyclobuten-1,2-dione; In tetrahydrofuran; dibutyl ether; at -78 ℃; for 1.16667h;

With trifluoroacetic anhydride; In tetrahydrofuran; dibutyl ether; for 0.183333h;

DOI:10.1039/c6ob01591c

Reference yield:

phenylmagnesium bromide + 3,4-diethoxy-3-cyclobuten-1,2-dione (5231-87-8) → 3-ethoxy-4-phenyl-3-cyclobutylene-1,2-dione (22118-95-2)

Guidance literature:

In diethyl ether;

upstream raw materials:

phenyllithium

3,4-diethoxy-3-cyclobuten-1,2-dione

Downstream raw materials:

4-(1,3-Dithian-2-yl)-3-ethoxy-4-hydroxy-2-phenylcyclobutenon

4-(1-n-butylethenyl)-3-ethoxy-4-hydroxy-2-phenyl-2-cyclobuten-1-one

3-Ethoxy-4-hydroxy-2-phenyl-4-(3-phenyl-1-propynyl)-2-cyclobuten-1-one

3-ethoxy-4-hydroxy-2-phenyl-4-(1-phenylethenyl)-2-cyclobuten-1-one