1-(2-Hydroxy-4-methoxyphenyl)-3-phenylpropan-1-one

Base Information

• Chemical Name: 1-(2-Hydroxy-4-methoxyphenyl)-3-phenylpropan-1-one
• CAS No.: 22141-31-7
• Molecular Formula: C16H16O3
• Molecular Weight: 256.301
• DSSTox Substance ID: DTXSID20361049
• Nikkaji Number: J2.161.823C
• Wikidata: Q82143154
• Metabolomics Workbench ID: 26918
• ChEMBL ID: CHEMBL1698547
• Mol file: 22141-31-7.mol

Synonyms:22141-31-7;1-(2-hydroxy-4-methoxyphenyl)-3-phenylpropan-1-one;1-(2-hydroxy-4-methoxyphenyl)-3-phenyl-1-propanone;2'-Hydroxy-4'-methoxydihydrochalcone;1-Propanone, 1-(2-hydroxy-4-methoxyphenyl)-3-phenyl-;2'-Hydroxy-4'-methoxy-3-phenylpropiophenone;AK-087/42718243;MLS001182616;CHEMBL1698547;SCHEMBL10829584;DTXSID20361049;HMS2780F17;LMPK12120443;SMR000476557

Chemical Property of 1-(2-Hydroxy-4-methoxyphenyl)-3-phenylpropan-1-one

Chemical Property:

• PSA: 46.53000
• LogP: 3.21630
• XLogP3: 3.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 256.109944368
• Heavy Atom Count: 19
• Complexity: 284

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=C(C=C1)C(=O)CCC2=CC=CC=C2)O

Technology Process of 1-(2-Hydroxy-4-methoxyphenyl)-3-phenylpropan-1-one

There total 15 articles about 1-(2-Hydroxy-4-methoxyphenyl)-3-phenylpropan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(E)-1-(2-hydroxy-4-methoxyphenyl)-3-phenylprop-2-en-1-one (39273-61-5,52923-29-2) → 4’-methoxy-2’-hydroxyl-dihydrochalcone (22141-31-7)

Guidance literature:

With cyclohexene; palladium on activated charcoal; for 0.583333h; Heating;

Reference yield: 92.0%

1-(2-hydroxy-4-methoxyphenyl)ethanone (552-41-0) + benzyl alcohol (100-51-6,185532-71-2) → 4’-methoxy-2’-hydroxyl-dihydrochalcone (22141-31-7)

Guidance literature:

With C₅₁H₃₉As₂N₃O₂RuS; sodium hydroxide; In toluene; at 105 ℃; for 8h;

DOI:10.1016/j.ica.2020.119887

Reference yield: 79.0%

1-[2-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-phenyl]-3-phenyl-propan-1-one (462611-06-9) → 4’-methoxy-2’-hydroxyl-dihydrochalcone (22141-31-7)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 ℃; for 0.75h;

DOI:10.1016/S0223-5234(01)01218-1

upstream raw materials:

7-methoxoyflavone

(E)-1-(2-hydroxy-4-methoxyphenyl)-3-phenylprop-2-en-1-one

2-Benzylidene-6-methoxy-3(2H)-benzofuranone

dimethyl sulfate

Downstream raw materials:

7-methoxoyflavone

2'-Hydroxy-4'-methoxy-α-hydroxymethyldihydrochalcone

4',4'''-Dimethoxy-2',2'''-bi(dihydro-chalkonyloxy)methane

7-methoxy-3-benzylchromone

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