L-Alanine, N-[(4-chlorophenoxy)[[(2S,5R)-5-(3,4-dihydro-5-methyl-2,4-dioxo-1(2H) -pyrimidinyl)-2,5-dihydro-2-furanyl]methoxy]phosphinyl]-, methyl ester

Base Information

• Chemical Name: L-Alanine, N-[(4-chlorophenoxy)[[(2S,5R)-5-(3,4-dihydro-5-methyl-2,4-dioxo-1(2H) -pyrimidinyl)-2,5-dihydro-2-furanyl]methoxy]phosphinyl]-, methyl ester
• CAS No.: 222021-16-1
• Molecular Formula: C20H23ClN3O8P
• Molecular Weight: 499.845
• Mol file: 222021-16-1.mol

Synonyms:

Chemical Property of L-Alanine, N-[(4-chlorophenoxy)[[(2S,5R)-5-(3,4-dihydro-5-methyl-2,4-dioxo-1(2H) -pyrimidinyl)-2,5-dihydro-2-furanyl]methoxy]phosphinyl]-, methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of L-Alanine, N-[(4-chlorophenoxy)[[(2S,5R)-5-(3,4-dihydro-5-methyl-2,4-dioxo-1(2H) -pyrimidinyl)-2,5-dihydro-2-furanyl]methoxy]phosphinyl]-, methyl ester

There total 1 articles about L-Alanine, N-[(4-chlorophenoxy)[[(2S,5R)-5-(3,4-dihydro-5-methyl-2,4-dioxo-1(2H) -pyrimidinyl)-2,5-dihydro-2-furanyl]methoxy]phosphinyl]-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

stavudin (3056-17-5) + (((1S)-(4-chlorophenoxy)-(1-methyl)oxycarbonylethyl)amino)phosphinyl chloride (217090-41-0) → 2',3'-didehydro-2',3'-dideoxythymidine 5'-(4-chlorophenyl (methoxyalaninyl)phosphate) (222021-16-1)

Guidance literature:

With 1-methyl-1H-imidazole; In tetrahydrofuran; for 16h; Ambient temperature;

DOI:10.1021/jm9803931

Reference yield:

2',3'-didehydro-2',3'-dideoxythymidine 5'-(4-chlorophenyl (methoxyalaninyl)phosphate) (222021-16-1) → 4-chloro-phenol (106-48-9,82344-39-6) + alaninyl-d4T-monophosphate (180076-92-0)

Guidance literature:

With Subtilisin Carlsberg serine protease; In methanol; water; at 20 ℃; Further Variations:; Reagents; Kinetics;

DOI:10.1016/j.ejmech.2004.11.015

Reference yield:

2',3'-didehydro-2',3'-dideoxythymidine 5'-(4-chlorophenyl (methoxyalaninyl)phosphate) (222021-16-1) → stavudine + 4-chloro-phenol (106-48-9,82344-39-6)

Guidance literature:

With Candida antarctica lipase B; In methanol; water; Further Variations:; Reagents; Enzyme kinetics;

DOI:10.1016/j.bmc.2005.04.083

upstream raw materials:

stavudin

(((1S)-(4-chlorophenoxy)-(1-methyl)oxycarbonylethyl)amino)phosphinyl chloride

Downstream raw materials:

4-chloro-phenol

alaninyl-d4T-monophosphate